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by AP 2 Sep 2010 at 3:01am Allergan Inc., the maker of wrinkle-smoothing Botox, has agreed to pay $600 million to settle a yearslong federal investigation into its marketing of the top-selling, botulin-based drug. by Reuters 2 Sep 2010 at 6:20am A study funded by Abbott Laboratories offered more detailed evidence that its weight-loss drug Meridia increases heart risks, prompting renewed calls by consumer advocates and others to pull the drug from the market. by HealthDay 2 Sep 2010 at 8:03am THURSDAY, Sept. 2 (HealthDay News) -- Many Americans have skewed perceptions when it comes to their weight, often believing they are lighter than they actually are, even when the scales are shouting otherwise, a new poll finds. by Reuters 2 Sep 2010 at 6:19am While staying mentally active in old age has been linked to a delayed onset of dementia, seniors who engage in such brain "exercise" may actually have a faster rate of decline once Alzheimer's is diagnosed, researchers reported Wedne... by AFP 2 Sep 2010 at 4:27am The chief of the UNAIDS agency said Thursday that global contributions to fighting the disease are dropping off for the first time in 15 years amid tough economic times. by Reuters 2 Sep 2010 at 11:21am Companies are cutting healthcare costs further amid a continuing sour economy, scaling back benefits and shifting a greater share of the expense to employees. by Reuters 2 Sep 2010 at 10:35am The estrogen-like compounds found in soy could help postmenopausal women get a better night's sleep, according to a small study. by Reuters 2 Sep 2010 at 12:19pm Women who start menstruating early may be at increased risk of asthma and poor lung function, new research shows. by Reuters 2 Sep 2010 at 2:33pm A cell phone text message -- and the buzz or beep that signals its arrival -- may not help a woman remember to pop her birth control pill, a new study suggests. by AFP 2 Sep 2010 at 1:05pm Researchers have discovered a promising new malaria drug with the potential to treat resistant strains of the deadly disease in a single dose, according to a study published Thursday in the journal Science. by Reuters 2 Sep 2010 at 2:38pm Pakistan's displaced flood victims say a lack of clean water and high temperatures are causing illnesses sweeping through relief camps with children most at risk. by Reuters 2 Sep 2010 at 1:54pm An experimental Novartis drug can clear malaria infection in mice with a single dose and scientists say it shows promise as a possible future treatment for one of the world's major killer diseases. by AFP 2 Sep 2010 at 2:16pm A groundbreaking new test can accurately diagnose drug-resistant tuberculosis (TB) in as little as two hours, researchers wrote in a study published Thursday in the New England Journal of Medicine. by Reuters 2 Sep 2010 at 1:46pm When it comes to changing health behaviors, it takes more than a far-flung network of friends on Facebook egging you on. It takes a jostling herd, U.S. researchers said on Thursday. by Reuters 2 Sep 2010 at 2:30pm A study funded by Abbott Laboratories offered more detailed evidence that its weight-loss drug Meridia increases heart risks, prompting renewed calls by consumer advocates and others to pull the drug from the market. |
2 Sep 2010 at 3:34pm Two agencies investigating claims that Procter & Gamble Co's Pampers Dry Max gave children severe diaper rash reported Thursday that they have found no specific cause linking the diapers to rashes. 30 Aug 2010 at 12:36pm
30 Aug 2010 at 11:16am NEW YORK (Reuters Health) - Contrary to popular belief, new mothers may often get a decent amount of sleep in their babies' first few months -- but it's not a good-quality sleep, a new study suggests. 30 Aug 2010 at 8:30am Emergency room visits for concussions have doubled in recent years for those 8- to 13-years old and tripled for teens ages 14 to 19, a new study says. The finding suggests the intensity of kids' sports has increased along with awareness of head injuries. 30 Aug 2010 at 9:24am NEW YORK (Reuters Health) - When it comes to treating very short kids with growth hormone, some doctors may be just as swayed by their own attitudes about being short as by data, suggests a new study. 29 Aug 2010 at 12:17pm
27 Aug 2010 at 5:07pm The U.S. Court of Appeals for the Federal Circuit upheld a decision last year by a special vaccine court, which concluded vaccines are not to blame for autism. 27 Aug 2010 at 6:55pm The U.S. birth rate has dropped for the second year in a row, and experts think the wrenching recession led many people to put off having children. The 2009 birth rate also set a record: lowest in a century. 24 Aug 2010 at 12:22pm NEW YORK (Reuters Health) - Taking high doses of vitamins C and E during pregnancy may not change a woman's risk of preterm delivery, according to a new study. 20 Aug 2010 at 12:25pm A Texas teenager who broke curfew is headed for a reluctant adventure in baby-sitting. 20 Aug 2010 at 12:25pm 19 Aug 2010 at 10:21am Children whose mothers were exposed to widely-used pesticides during pregnancy may be at increased risk of developing an attention disorder by age 5, a new study shows. 19 Aug 2010 at 1:30pm More U.S. teens are getting recommended vaccines against certain cancers, meningitis and infectious diseases, government researchers reported on Thursday. 17 Aug 2010 at 3:03pm
17 Aug 2010 at 12:18pm The youngest kindergarteners are more likely to be diagnosed with attention deficit hyperactivity disorder than their older peers, a study says. The finding raises concerns that less mature kids are being misdiagnosed. |
3 Jun 2009 at 3:54am by By ANN M. MORRISON 14 Jul 2010 at 11:00pm by By JENNIFER A. KINGSON 30 Jun 2010 at 11:00pm by By CATHERINE SAINT LOUIS 17 Mar 2010 at 11:00pm The pursuit of beauty increases anxiety as women age; two doctors and former models have a book to suggest answers. by By CATHERINE SAINT LOUIS 15 Jan 2010 at 11:00pm Dermatologists nationwide are seeing women of Hispanic and African descent with severe side effects from misuse of skin-lightening creams; many of creams are sold in beauty shops, bodegas and online even though they contain prescription-strength ingredients; Hyprogel, made in Germany, contains powerful steroid and includes warning to use only as directed by doctor; no major studies have focused on use of such creams in US; former baseball player Sammy Sosa says that cream to 'soften' his skin h... by By HILARY HOWARD 6 Jan 2010 at 11:00pm by By CATHERINE SAINT LOUIS 5 Aug 2009 at 11:00pm Are you having sex with your socks on? If so, it may be time to make peace with your feet.by By NATASHA SINGER 18 Mar 2008 at 11:00pm Two specialties concerned with physical appearance are among the most competitive residency programs.by By JOANNE KAUFMAN 27 Oct 2007 at 11:00pm Luminaries tended by Barbara Singer range from Lynda Bird Johnson, who called her Ma’am, to Jackie Kennedy, who showed up sans underwear.by By NATASHA SINGER 27 Jun 2007 at 11:00pm Paying a lot while trying very hard to look like you are not trying very hard.by By JOSH PATNER 14 Apr 2007 at 11:00pm How to be 96 and look like Kitty Carlisle Hart.by By S.S. FAIR 14 Apr 2007 at 11:00pm The Samurai goes for the faux glow.by By NATASHA SINGER 3 May 2006 at 11:00pm As part of a move away from decorated nails, an increasing number of luxury salons and spas offer intensive foot care treatments.by By JASON HOROWITZ (NYT) 1 Sep 2003 at 11:00pm Entrants in Miss Italia beauty contest experience reaction to traces of nickel found in make-up; metal caused unattractive skin reaction in at least 40 girls; judges had already cast ballots for finalists, but some girls eliminated are considering lawsuits by By ELIZABETH HAYT 13 Nov 1999 at 11:00pm Article on Botox injections, hydrotherapy and other skin-enhancing services provided by dermatologists who are reinventing themselves as beauty gurus; Seth Matarasso, Frederic Brandt, Laurie Polis and other doctors comment; photos by By PAMELA G. HOLLIE 15 Feb 1985 at 11:00pm In Oak Brook, Ill., where Blistex Inc. has its headquarters, this winter has been the most severe in years. Not coincidentally, sales of Blistex's cold weather lip balms are better than ever. ''This is the peak season for companies like ours,'' said Donald Turney, marketing manager for Blistik lip products. Every snow cloud has its silver lining. Harsh, cold and dry weather is good news for the people who live off lip balms and face and body lotions. Sales of some skin care products increase 20... |
by New, D., Bahrami, S., Malone, J., Callen, J. P. 16 Aug 2010 at 2:42pm Background Atypical fibroxanthoma (AFX) is a low-grade sarcoma usually occurring on sun-damaged skin of the head and neck in elderly patients. Metastatic disease has been reported very rarely. The potential aggressiveness of AFX is controversial. Observations We describe herein a patient who developed metastatic disease in cervical lymph nodes. Our patient was an 87-year-old man with a 7-week history of a rapidly growing AFX presenting as a 1.5-cm sessile nodule on his right mandible. Two months following excision, the patient developed cervical lymphadenopathy. Histopathologic analysis of the cervical lymph nodes revealed spindle-cell tumors with histologic characteristics identical to those of the primary AFX, and the tumors were immunonegative for cytokeratin MNF-116 and S-100. In addition, we review and analyze cases from the literature and articles related to immunohistochemical stains used to diagnose AFX. Conclusions Atypical fibroxanthoma is a diagnosis of exclusion, and only a small number of metastatic AFX cases have been reported. A review of the literature pertaining to immunohistochemical stains suggests the potential benefit of use of CD10, procollagen I, CD99, CD117, p63, and LN-2 in differentiating AFX from other spindle-cell tumors. The metastatic potential of AFX may not be fully appreciated, and clinicians should be reminded of its potential aggressive behavior. by Qureshi, A. A., Dominguez, P. L., Choi, H. K., Han, J., Curhan, G. 16 Aug 2010 at 2:41pm Objectives To evaluate the independent association between alcohol consumption and risk of developing psoriasis and to determine if this risk is associated with different types of alcoholic beverages. Design A prospective study of female nurses who were followed up from 1991 to 2005. Setting Nurses' Health Study II, a cohort of 116 671 US women aged 27 to 44 years in 1991. Participants The study population included 82 869 women who reported amount and type of alcohol intake on biennial questionnaires. We excluded participants with a history of psoriasis prior to 1991. Main Outcome Measure Self-report of incident physician-diagnosed psoriasis. For a sensitivity analysis, we had a subset of confirmed psoriasis cases. Results There were 1150 cases of incident psoriasis, 1069 of which were used for analysis. Compared with women who did not drink alcohol, the multivariate relative risk (RR) of psoriasis was 1.72 (95% confidence interval [CI], 1.15-2.57) for an alcohol consumption of 2.3 drinks/wk or more. When examined by type of alcoholic beverage, there was an association between psoriasis and nonlight beer intake (multivariate RR for ≥5 drinks/wk, 1.76; 95% CI, 1.15-2.69); light beer, red wine, white wine, and liquor were not significantly associated with psoriasis risk. The association with nonlight beer intake became stronger in a subset of confirmed psoriasis cases (multivariate RR for ≥5 drinks/wk, 2.29; 95% CI, 1.36-3.85). Conclusions Nonlight beer intake is associated with an increased risk of developing psoriasis among women. Other alcoholic beverages did not increase the risk of psoriasis in this study. by Duffy, K. J., Runge-Samuelson, C., Bayer, M. L., Friedland, D., Sulman, C., Chun, R., Kerschner, J. E., Metry, D., Adams, D., Drolet, B. A. 16 Aug 2010 at 2:41pm Background PHACE syndrome describes a spectrum of anomalies associated with large facial infantile hemangiomas and characterized by posterior fossa malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities. With improved recognition and imaging practices of infants with PHACE syndrome, additional associations have been identified. To our knowledge, the potential association of ipsilateral hearing loss and PHACE syndrome has not been previously emphasized. Observations We describe 6 patients, 4 with definite and 2 with probable PHACE syndrome, according to the new diagnostic criteria, and associated auditory deficiencies. One patient had isolated conductive hearing loss; 2 patients had isolated sensorineural hearing loss; 1 patient had mixed hearing loss (both conductive and sensorineural components); and 1 patient had hearing loss that was inconclusive at the time. Also, 1 patient had conductive loss and auditory neuropathy and auditory dyssynchrony. Four of the 6 patients had magnetic resonance imaging features of lesions consistent with intracranial hemangiomas involving auditory structures. All 6 patients had facial hemangiomas in a nearly identical distribution ipsilateral to the ear with the hearing loss, with involvement of the proposed facial segments S1 and S3, the affected ear, the periauricular region, and the midoccipital area of the scalp. Conclusions There is an underrecognized risk of hearing loss in patients with PHACE syndrome, although the exact nature of such deficiencies can vary. Patients with PHACE syndrome who have cutaneous hemangiomas involving the ear should be evaluated for intracranial hemangiomas and monitored for hearing loss. Early detection and therapy of intracranial hemangiomas may slow or stop tumor growth, resultant hearing loss, and structural damage. by Samimi, S., Benoit, B., Evans, K., Wherry, E. J., Showe, L., Wysocka, M., Rook, A. H. 16 Aug 2010 at 2:40pm Objectives To investigate the expression profile of programmed death-1 (PD-1) on T cells derived from patients with cutaneous T-cell lymphoma (CTCL), analyze a potential mechanism responsible for upregulation of PD-1, and assess the correlation between blockade of its signaling pathway and improvement in immunological function. Design Translation research study. Setting University medical center. Participants Patients with Sézary syndrome, patients with mycosis fungoides, and healthy volunteers. Main Outcome Measures Programmed death-1 expression on T cells by flow cytometry and interferon (IFN-) production by enzyme-linked immunosorbent assay. Results We report significantly increased PD-1 expression on CD4+ T cells from patients with Sézary syndrome compared with CD4+ T cells from patients with mycosis fungoides and healthy volunteers. Both CD26– and CD26+ populations of CD4+ T cells demonstrated increased expression of PD-1, which was upregulated by the engagement of the T-cell receptor with anti-CD3/CD28 antibodies. In addition, blockade of the signaling pathway with blocking antibodies to PD-1 or its ligand PD-L1 led to an increase in the capacity to produce IFN- among some patients. Finally, longitudinal studies of 1 patient revealed a progressive decrease in PD-1 expression on CD4+ T cells with improvement of clinical disease. Conclusion Our data imply that increased PD-1 expression in Sézary syndrome may play a role in attenuating the immune response and provide further insight into the immunosuppressive nature of CD4+ T cells in Sézary syndrome and suggest another potential means of targeted therapy for these patients. by Chen, Y.-C., Chiu, H.-C., Chu, C.-Y. 16 Aug 2010 at 2:40pm Objective To investigate the clinical and pathologic features of patients with drug reaction with eosinophilia and systemic symptoms (DRESS) in Taiwan. Design Case series and retrospective analysis. Setting A medical referral center in Northern Taiwan. Patients Sixty cases of DRESS occurring from June 1998 to May 2008. Main Outcome Measures Clinical characteristics for specific drugs and important prognostic factors in DRESS. Results Patients ranged in age from 6 to 90 years (mean age, 51 years). The female to male ratio was 1.3 to 1. The most common culprit drugs were allopurinol, phenytoin, and dapsone. Exanthematous eruption was the most common skin manifestation, but purpurae and blisters were also observed. Hepatic (80%), renal (40%), and pulmonary (33%) involvement were also common. The overall mortality rate was 10%. Allopurinol-induced DRESS was characterized by preceding chronic renal insufficiency and frequent renal involvement. Pancytopenia indicated a poor prognosis. Conclusions Drug reaction with eosinophilia and systemic symptoms has a variable clinical presentation, and its definition requires clarification. It may be a heterogeneous syndrome with some particular patterns related to different drugs. Early diagnosis and prompt discontinuation of offending drug regimens are essential. by DeFazio, J. L., Marghoob, A. A., Pan, Y., Dusza, S. W., Khokhar, A., Halpern, A. 19 Jul 2010 at 2:48pm Objective To assess current practices and recommendations of US physicians regarding depth of excision for melanomas of varying histologic thicknesses. Design A 2-page, 13-question survey of depth of excision practices for the treatment of melanoma was developed and distributed. Setting Both private and academic settings. Participants A total of 1184 US physicians (1000 dermatologists and 184 melanoma specialists) were sent the survey. The 184 melanoma specialists included dermatologists, oncologists, and surgeons working in pigmented lesion clinics. Main Outcome Measures Depth of excision practices reported for melanomas of varying histologic thicknesses and comparison of treating physician groups. Results were tabulated, and descriptive frequencies were used to describe demographics and survey responses. Results The final study analysis included 498 completed surveys. The overall response rate was 45% (498 of 1097 [1184 total respondents – 87 ineligibles]). The response rate for the specialists was 63% (115 of 183 [184 total respondents – 1 ineligible]), and for nonspecialist dermatologists it was 43% (383 of 892 [1000 total respondents – 108 ineligibles]). Specialists were more likely to practice in an urban setting than were nonspecialist dermatologists (78% vs 46%) (P < .001). Fifty-eight percent of nonspecialist dermatologists reported more than 400 patient visits per month compared with only 16% of specialists (P < .001). While specialists reported fewer patient visits per month, 51% reported diagnosing over 20 invasive melanomas in the previous year compared with 11% of nonspecialist dermatologists. There was no significant difference in excision depth reported among the specialties for melanoma in situ (P = .15). For invasive melanoma, significant differences were observed among treating groups, with the greatest incongruence reported for thin invasive melanoma (<0.50 mm, P = .02; 0.50-0.75 mm, P < .001; and 0.76-1.00 mm, P < .001). Specialist nondermatologists consistently reported excising more deeply than specialist dermatologists and nonspecialist dermatologists. More specialist nondermatologists report excising to the fascia for thin invasive melanoma than do both specialist and nonspecialist dermatologists. For thicker melanomas (>1.00 mm), differences in excision depths among treating physician groups decreased: most physicians in each group reported excising to the fascia. Conclusions There is considerable variation among physician groups with regard to depth of excision practices for the treatment of melanoma. Given the current lack of clinical data available, studies assessing depth of excision and patient outcomes are needed to better define our surgical management of melanoma. Published online July 19, 2010 (doi:10.1001/archdermatol.2010.156). 16 Aug 2010 at 2:51pm 16 Aug 2010 at 2:51pm 16 Aug 2010 at 2:51pm by St Pierre, S. A., Rommel, J., Ciurea, A., Fife, D., Yoo, S. S., Martini, M., Kuzel, T. M., Wayne, J., Rademaker, A., West, D. P., Alam, M. 16 Aug 2010 at 2:51pm by Robinson, J. K. 16 Aug 2010 at 2:51pm by Ryan, C., Moran, B., McKenna, M. J., Murray, B. F., Brady, J., Collins, P., Rogers, S., Kirby, B. 16 Aug 2010 at 2:51pm Objectives To determine whether narrowband UV-B (NB–UV-B) may mediate its beneficial effect on psoriasis by increasing vitamin D levels, and to assess the effect of NB–UV-B on vitamin D status in patients with psoriasis in wintertime. Design A prospective controlled study from October 2008 to February 2009. Setting A dermatology outpatient department at a university teaching hospital. Patients Thirty consecutive patients with psoriasis treated with NB–UV-B and 30 control patients with psoriasis were recruited. Control patients were recruited within 1 week of treated patients to control for seasonal variation of serum 25-hydroxyvitamin D [25(OH)D] levels. One patient with photoaggravated psoriasis was withdrawn from the study. Intervention Narrowband UV-B was administered 3 times per week. Main Outcome Measure Serum 25(OH)D was measured at baseline, after 4 weeks and at completion of treatment. Results Levels of serum 25(OH)D increased significantly (P < .001) from a median (range) of 23 (9-46) ng/mL at baseline to 59 (32-112) ng/mL at the end of NB–UV-B treatment compared with no change in the control group. The change in serum 25(OH)D level correlated with the number of exposures of NB–UV-B (r = 0.61; P < .001) and cumulative UV-B dose (r = 0.47; P = .01) but not with treatment response. At the end of the study, all patients in the treatment group were vitamin D sufficient, but 75% of the control group had vitamin D insufficiency [serum 25(OH)D level <20 ng/mL]. In a multiple regression model, prior phototherapy was the sole predictor of baseline serum 25(OH)D level (r2 = 0.13; P = .006), whereas the number of exposures of NB–UV-B predicted change in serum 25(OH)D level (r2 = 0.38; P = .001). Conclusions Narrowband UV-B effectively increases serum 25(OH)D level while clearing psoriasis. Up to 75% of Irish patients with psoriasis were shown to be vitamin D insufficient during wintertime. by Ziefle, S., Schule, D., Breuninger, H., Schippert, W., Moehrle, M. 16 Aug 2010 at 2:51pm Objective To compare ex vivo confocal laser scanning microscopy (CLSM), which offers rapid images without the need for tissue processing, vs 3-dimensional histologic imaging, the criterion standard treatment for basal cell carcinomas in high-risk areas of the face. Design Single-center prospective trial. Setting Dermatosurgical unit of a university hospital. Patients Seventy-two consecutive surgically removed basal cell carcinomas were examined using CLSM vs standard paraffin-embedded 3-dimensional histologic imaging. Interventions A total of 312 images, including 73 midsections, 196 lateral margins, 23 "muffins," and 20 "bread loaf sections," were obtained using CLSM. Immediately after surgery, the CLSM images were evaluated by the surgeon. The following day, the 3-dimensional histologic slides were evaluated and compared with the CLSM images. Main Outcome Measures Diagnostic accuracy of ex vivo CLSM to detect tumor strands of basal cell carcinomas and the practicality of using CLSM vs 3-dimensional histologic slides in micrographic surgery. Results The sensitivity of CLSM reached 94.0% in midsections, 73.7% in lateral margins, 80.0% in muffins, and 80.0% in bread loaf sections. The CLSM images were evaluated by the surgeon within 7.5 minutes. Conclusions Confocal laser scanning microscopy lacks high sensitivity to detect small tumor strands of basal cell carcinomas. In the future, CLSM may represent a time-saving and less expensive alternative to cryostat histopathologic examination. by Kiiski, V., de Vries, E., Flohil, S. C., Bijl, M. J., Hofman, A., Stricker, B. H. C., Nijsten, T. 16 Aug 2010 at 2:51pm Objective To investigate the incidence of single and multiple basal cell carcinoma (BCC) lesions and associated risk factors. Design A prospective, population-based cohort study (from January 1, 1990, through December 31, 2007). Setting Two cohorts of 10 994 Dutch people, 55 years or older, were studied in 1990 (first cohort) and 1999 (second cohort). Patients Patients with BCC lesions were identified from the Dutch national pathology laboratories network, hospitals, and general practices. Main Outcome Measures The associations between determinants and single and multiple BCC lesions were studied by estimating odds ratios (ORs) and hazards ratios, using multivariate logistic regression and Andersen-Gill models, respectively. Results Of the eligible 10 820 cohort members, 524 (4.8%) had BCC, of whom 361 had single and 163 (31.1%) had multiple lesions. Age and red hair were significant risk factors for a first BCC lesion in a multivariate model. In the Andersen-Gill model, people who developed a first BCC lesion after 75.0 years of age were significantly less likely to develop multiple lesions (≥75.0 years adjusted OR, 0.58; 95% confidence interval [CI], 0.47-0.71). Red hair (adjusted OR, 1.43; 95% CI, 1.05-1.94), high educational level (1.42; 1.12-1.81), and a first BCC lesion located on the upper extremities (1.49; 1.02-2.15) were associated with a significantly increased risk of developing multiple lesions. Conclusion Patients who are relatively young at their first BCC diagnosis, those with red hair, those with higher socioeconomic status, and/or those with a BCC lesion on their upper extremities have a higher risk of developing multiple lesions and require closer follow-up over time. by Kirsner, R. S., Warriner, R., Michela, M., Stasik, L., Freeman, K. 16 Aug 2010 at 2:51pm Objective To assess the clinical use of advanced biological therapies in treating diabetic foot ulcers in practice and the effect of these therapies on time to healing. Design A retrospective cohort study. Setting A validated wound care database from January 1, 2001, through December 31, 2004. Participants Two thousand five hundred seventeen patients with diabetic neuropathic foot ulcers. Intervention Patients who received advanced biological therapy (ie, Apligraf, Regranex, or Procuren). Main Outcome Measure Time to healing after initial use of advanced biological therapy. This was derived using Kaplan-Meier estimates and the Ederer least squares method after adjusting for covariates, which were assessed using generalized estimating equations and Cox proportional hazards regression modeling. Results Advanced biological therapy was used, on average, within 28 days from the first wound clinic visit and associated with a median time to healing of 100 days. Regardless of the advanced biological therapy used, wounds with larger wound area, more severe wound grades, longer duration of wound prior to the first visit, and prolonged time to treatment with advanced biological therapies were significantly associated with longer time to healing. Wounds treated with engineered skin as the first advanced biological therapy were 31.2% more likely to heal than wounds first treated with topical recombinant growth factor (P < .001), and 40.0% more likely to heal than those first treated with platelet releasate (P = .01). Wound size, wound grade, duration of wound, and time to initiation of advanced biological therapy affected the time to healing. Conclusions Advanced biological therapies were used, on average, within 1 month, and improved healing of refractory diabetic foot ulcers. Differences on outcomes among advanced biological therapies were noted. |
25 Aug 2010 at 5:42pm (MedPage Today) -- A novel drug targeted to a common mutation behind melanoma appears effective in skin tumors that carry the mutation, according to early results. 18 Aug 2010 at 8:01am (MedPage Today) -- Engineered skin significantly improved healing of diabetic foot ulcers compared with other advanced biologic therapies, according to an analysis of a larger wound care database. 17 Aug 2010 at 11:09am (MedPage Today) -- In patients with psoriasis, narrow-band ultraviolet-B light increased serum vitamin D levels while clearing the condition, researchers said. 16 Aug 2010 at 4:47pm (MedPage Today) -- Women who drink five or more regular beers a week may double their risk of developing psoriasis, a prospective cohort study found. 16 Aug 2010 at 3:00pm (MedPage Today) -- Redheads appear to be at the highest risk for developing multiple basal cell carcinomas, according to a Dutch population-based study. 16 Aug 2010 at 3:00pm (MedPage Today) -- People with psoriasis have an increased risk of depression, anxiety, and suicidal thoughts, researchers reported. 11 Aug 2010 at 5:32pm (MedPage Today) -- Bone marrow transplantation may help fight a rare genetic blistering skin disease -- but could be too risky for any but the severest cases, according to a small study. 20 Jul 2010 at 8:30am (MedPage Today) -- Obesity in early adulthood is an independent risk factor for the development of psoriatic arthritis, a large case series found. 19 Jul 2010 at 3:00pm (MedPage Today) -- Melanoma incidence among some nonwhites in Florida differs from other parts of the country -- suggesting new public health concerns in an area with high ultraviolet light exposure, according to a new study. 24 Jun 2010 at 12:01pm SAN DIEGO (MedPage Today) -- Growth hormone therapy improved glucocorticoid-induced growth failure and metabolic abnormalities in boys with muscular dystrophy, according to a small case series study presented here. 21 Jun 2010 at 3:00pm (MedPage Today) -- There has been a steady increase in cancers of the sweat glands and hair follicles -- cutaneous appendageal carcinomas -- since the late 1970s, although the incidence of the tumors remains low, researchers found. 5 Jun 2010 at 9:30am CHICAGO (MedPage Today) -- The first-ever overall survival benefit with any treatment in a metastatic melanoma clinical trial has been reported with the immune-stimulating agent ipilimumab. 26 May 2010 at 11:05pm (MedPage Today) -- Indoor tanning is associated with a 74% higher risk of melanoma, researchers said. 18 May 2010 at 4:20pm (MedPage Today) -- There is no risk of fracture associated with vitamin A analogues used to treat such skin conditions as acne and psoriasis, Danish researchers said. 18 May 2010 at 8:14am (MedPage Today) -- An appearance-based intervention to prevent skin cancer was effective in reducing indoor tanning among college women for reasons other than personal appearance, a secondary analysis from a randomized trial found. |
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