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Colon Cancer News
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by AP 2 Sep 2010 at 3:01am Allergan Inc., the maker of wrinkle-smoothing Botox, has agreed to pay $600 million to settle a yearslong federal investigation into its marketing of the top-selling, botulin-based drug. by Reuters 2 Sep 2010 at 6:20am A study funded by Abbott Laboratories offered more detailed evidence that its weight-loss drug Meridia increases heart risks, prompting renewed calls by consumer advocates and others to pull the drug from the market. by HealthDay 2 Sep 2010 at 8:03am THURSDAY, Sept. 2 (HealthDay News) -- Many Americans have skewed perceptions when it comes to their weight, often believing they are lighter than they actually are, even when the scales are shouting otherwise, a new poll finds. by Reuters 2 Sep 2010 at 6:19am While staying mentally active in old age has been linked to a delayed onset of dementia, seniors who engage in such brain "exercise" may actually have a faster rate of decline once Alzheimer's is diagnosed, researchers reported Wedne... by AFP 2 Sep 2010 at 4:27am The chief of the UNAIDS agency said Thursday that global contributions to fighting the disease are dropping off for the first time in 15 years amid tough economic times. by Reuters 2 Sep 2010 at 11:21am Companies are cutting healthcare costs further amid a continuing sour economy, scaling back benefits and shifting a greater share of the expense to employees. by Reuters 2 Sep 2010 at 10:35am The estrogen-like compounds found in soy could help postmenopausal women get a better night's sleep, according to a small study. by Reuters 2 Sep 2010 at 12:19pm Women who start menstruating early may be at increased risk of asthma and poor lung function, new research shows. by Reuters 2 Sep 2010 at 2:33pm A cell phone text message -- and the buzz or beep that signals its arrival -- may not help a woman remember to pop her birth control pill, a new study suggests. by AFP 2 Sep 2010 at 1:05pm Researchers have discovered a promising new malaria drug with the potential to treat resistant strains of the deadly disease in a single dose, according to a study published Thursday in the journal Science. by Reuters 2 Sep 2010 at 2:38pm Pakistan's displaced flood victims say a lack of clean water and high temperatures are causing illnesses sweeping through relief camps with children most at risk. by Reuters 2 Sep 2010 at 1:54pm An experimental Novartis drug can clear malaria infection in mice with a single dose and scientists say it shows promise as a possible future treatment for one of the world's major killer diseases. by AFP 2 Sep 2010 at 2:16pm A groundbreaking new test can accurately diagnose drug-resistant tuberculosis (TB) in as little as two hours, researchers wrote in a study published Thursday in the New England Journal of Medicine. by Reuters 2 Sep 2010 at 1:46pm When it comes to changing health behaviors, it takes more than a far-flung network of friends on Facebook egging you on. It takes a jostling herd, U.S. researchers said on Thursday. by Reuters 2 Sep 2010 at 2:30pm A study funded by Abbott Laboratories offered more detailed evidence that its weight-loss drug Meridia increases heart risks, prompting renewed calls by consumer advocates and others to pull the drug from the market. |
3 Jun 2009 at 3:54am |
by Cancer Genetics and Cytogenetics 2 Sep 2010 at 2:28am With the advancement of massively parallel sequencing technologies and the advent of the International Cancer Genome Consortium (ICGC), we are poised to see an exponential growth of sequencing data for numerous types of cancers. These data will allow identification of countless somatic mutations that cause cancers and will be a significant driver for cancer research, thus enabling the identification of new targets for therapy. (Source: Cancer Genetics and Cytogenetics)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising. by Cancer Genetics and Cytogenetics 2 Sep 2010 at 2:28am Abstract: In peripheral blood, cell-free methylated DNA has been reported to be a useful biomarker of noninvasive blood screening for the detection of colorectal cancer (CRC), including the genes ALX homeobox 4Â (ALX4), septin 9 (SEPT9), or transmembrane protein with EGF-like, and two follistatin-like domains 2 (TMEFF2). Here we report a multiplex MethyLight polymerase chain reaction (PCR) assay that simultaneously detected the methylation status of ALX4, SEPT9, and TMEFF2, as well as quantifying methylation level of these genes in a total of 127 fresh tissue samples and 182 peripheral blood samples from CRC patients. Using the multiplex MethyLight assay, methylated ALX4, SEPT9, and TMEFF2 occurred in 56, 78, and 75% of CRC tissue samples and in 48, 75, and 71% of peripheral blood samples ... by CTV Health 1 Sep 2010 at 12:23pm An inexpensive drug that's already used to treat type 2 diabetes could find new life as a cancer fighter, with two new studies suggesting it fights off colon cancer and even prevents lung cancer in smokers. (Source: CTV Health) by Cardiovascular Business News 1 Sep 2010 at 9:44am The CT Colonography (CTC) Coalition has called on the U.S. Preventive Services Task Force (USPTF) to reconsider its recommendation regarding virtual colorectal cancer screening, following the statement issued by the task force maintaining that further research is still required to make a conclusive recommendation regarding CTC. (Source: Cardiovascular Business News) by Genome Research 1 Sep 2010 at 8:02am Genome-wide association studies (GWAS) routinely identify risk variants in noncoding DNA, as exemplified by reports of multiple single nucleotide polymorphisms (SNPs) associated with prostate cancer in five independent regions in a gene desert on 8q24. Two of these regions also have been associated with breast and colorectal cancer. These findings implicate functional variation within long-range cis-regulatory elements in disease etiology. We used an in vivo bacterial artificial chromosome (BAC) enhancer-trapping strategy in mice to scan a half-megabase of the 8q24 gene desert encompassing the prostate cancer-associated regions for long-range cis-regulatory elements. These BAC assays identified both prostate and mammary gland enhancer activities within the region. We demonstrate that the 8... by Genome Research 1 Sep 2010 at 8:02am Aberrant DNA methylation frequently occurs at gene promoters during cancer progression. It is important to identify these loci because they are often misregulated and drive tumorigenesis. Bisulfite sequencing is the most direct and highest resolution assay for identifying aberrant promoter methylation. Recently, genomic capture methods have been combined with next-generation sequencing to enable genome-scale surveys of methylation in individual samples. However, it is challenging to validate candidate loci identified by these approaches because an efficient method to bisulfite sequence more than 50 differentially methylated loci across a large number of samples does not exist. To address this problem, we developed Bisulfite Patch PCR, which enables highly multiplexed bisulfite PCR and sequ... by Cancer Network 1 Sep 2010 at 6:00am Male sex, but not race, predicted colon polyp prevalence, suggesting that African Americans may not benefit from earlier screening. (Source: Cancer Network) by Sleep 1 Sep 2010 at 3:38am Conclusion: In a public hospital, primary care patients were less likely to be referred for PSG compared to mammogram and endoscopy. Uninsured patients were more likely to be referred for PSG than those with private insurance. Further studies are needed to address the low PSG referral rates in high-risk populations. Keywords: Sleep apnea, primary care, referral, health care delivery, socioeconomic status (Source: Sleep) by Health News from Medical News Today 1 Sep 2010 at 1:00am Researchers at the Faculty of Health Sciences have succeeded in decoding the genetic key that gives particular intestinal cells their identity. With this knowledge of the complex network of genes the researchers now hope to stop colon cancer by activating special anti-cancer genes. Colon sloughs lining The intestines have to work properly if we are to benefit from the food we eat. Digestive juices must be secreted, the food broken down into smaller components and Human intestines then transported through the gut wall and onwards to muscles and organs... (Source: Health News from Medical News Today)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising. by Gastroenterology and Liver Diseases Specialist Library - Prevention 1 Sep 2010 at 12:19am âStocking up on vitamin D supplements and enjoying the summer sun could cut the risk of a host of diseases,â reported the Daily Mail. This news story is based on a study that investigated how vitamin D might influence the risk of certain diseases by affecting the activity of genes. It found that vitamin D binds directly to genes associated with several common autoimmune diseases, including multiple sclerosis, type 1 diabetes, rheumatoid arthritis and colorectal cancer. Studies of this kind add to our knowledge of the function of vitamin D, and will be used to assess the guidelines for recommended vitamin D intake. What does NHS Choices make of this study? This is a valuable addition to our knowledge of the effects of vitamin D in the cells and how it might affect our risk of certain di... by MedWire News - Gastroenterology 1 Sep 2010 at 12:16am Study findings confirm that celiac disease patients have a similar risk for colorectal cancer to the general population. (Source: MedWire News - Gastroenterology) by International Journal of Cancer 31 Aug 2010 at 11:15pm (Source: International Journal of Cancer) by Cancer Research 31 Aug 2010 at 10:07pm The pyrrolobenzodiazepines (PBD) are naturally occurring antitumor antibiotics, and a PBD dimer (SJG-136, SG2000) is in phase II trials. Many potent PBDs contain a C2-endo-exo unsaturated motif associated with the pyrrolo C-ring. The novel compound SG2202 is a PBD dimer containing this motif. SG2285 is a water-soluble prodrug of SG2202 in which two bisulfite groups inactivate the PBD N10-C11 imines. Once the bisulfites are eliminated, the imine moieties can bind covalently in the DNA minor groove, forming an interstrand cross-link. The mean in vitro cytotoxic potency of SG2285 against human tumor cell lines is GI50 20 pmol/L. SG2285 is highly efficient at producing DNA interstrand cross-links in cells, but they form more slowly than those produced by SG2202. Cellular sensitivity to SG2285 ... by Cancer Research 31 Aug 2010 at 10:07pm The hepatocyte growth factor (HGF)-MET pathway supports several hallmark cancer traits, and it is frequently activated in a broad spectrum of human cancers (http://www.vai.org/met/). With the development of many cancer drugs targeting this pathway, there is a need for relevant in vivo model systems for preclinical evaluation of drug efficacy. Here, we show that production of the human HGF ligand in transgenic severe combined immunodeficient mice (hHGFtg-SCID mice) enhances the growth of many MET-expressing human carcinoma xenografts, including those derived from lung, breast, kidney, colon, stomach, and pancreas. In this model, the MET-specific small-molecule kinase inhibitor SGX523 partially inhibits the HGF-dependent growth of lung, breast, and pancreatic tumors. However, much greater gr... by Cancer Research 31 Aug 2010 at 10:07pm In this study, we examined the expression and function of VGSCs in a panel of colon cancer cell lines by electrophysiologic recordings. Na+ channel activity and invasive potential were inhibited pharmacologically by tetrodotoxin or genetically by small interfering RNAs (siRNA) specifically targeting SCN5A. Clinical relevance was established by immunohistochemistry of patient biopsies, with strong Nav1.5 protein staining found in colon cancer specimens but little to no staining in matched-paired normal colon tissues. We explored the mechanism of VGSC-mediated invasive potential on the basis of reported links between VGSC activity and gene expression in excitable cells. Probabilistic modeling of loss-of-function screens and microarray data established an unequivocal role of VGSC SCN5A as a h... |
31 Aug 2010 at 1:00am Researchers have succeeded in decoding the genetic key that gives particular intestinal cells their identity. With this knowledge of the complex network of genes the researchers now hope to stop colon cancer by activating special anti-cancer genes. 30 Aug 2010 at 4:00am A new analysis finds that cancer patients from poorer communities have a greater chance of dying prematurely than individuals from more affluent backgrounds even though cancer stage at time of diagnosis is similar across socioeconomic groups. 27 Aug 2010 at 7:00pm A new analysis has found that while colon cancer rates have remained steady over the past several decades among people under the age of 40, rectal cancer rates are increasing in this population across races and in both sexes. 25 Aug 2010 at 1:00am Colorectal cancer is a leading cause of death worldwide. Hydrophobic proteins are a class of proteins that are involved in many cellular functions in the body. A group of researchers from Malaysia analyzed differentially expressed hydrophobic proteins in colorectal cancer and normal tissues. Four hydrophobic proteins were found to be highly expressed in colorectal cancer tissues, these proteins may serve as potential biomarkers for colorectal cancer that can be used for its detection and treatment. 23 Aug 2010 at 4:00pm Researchers have developed a nano-sized vehicle that can deliver chemotherapy drugs directly into cancer cells while avoiding interaction with healthy cells. The vehicle is very similar to a 'cluster bomb' and can be used to treat many different types of tumors, including lung, blood, colon and brain cancers. 19 Aug 2010 at 11:00pm Although the medical community has already accepted that colorectal cancer (CRC) screening is cost effective and saves lives, researchers have found that computed tomography colonography (CTC or virtual colonoscopy) not only identifies CRC but also doubles the yield of identifying significant early extracolonic (outside the colon) lesions, resulting in lives saved, according to a new study. 17 Aug 2010 at 4:00pm Adult stem cells that are vital for airway repair in the lung but that persist in areas where pre-cancerous lesions are found are associated with a poor prognosis in patients who develop cancer, even those with early stage disease, researchers have found. 4 Aug 2010 at 10:00am Paying close attention to routine blood test results can be an effective screening system for colon cancer which, when diagnosed early enough, can be treated effectively. A new study shows that most patients with colon cancer have a history of consistently declining hemoglobin levels up to four years before being diagnosed with the disease. 3 Aug 2010 at 7:00am An experimental vaccine based on a virus that causes encephalitis in the wild appears to block tumor growth in some cases of advanced cancer, according to new research. Scientists say the vaccine is able to stimulate an immune response, even in the face of profound immune system suppression, a condition most patients with advanced cancer experience. 29 Jul 2010 at 11:00pm CD74 is a protein expressed by cells of the immune system. A research group in Israel finds that CD74 is expressed on colon epithelial cells of mice, as well as on a malignant cell line from mouse colon. Stimulation of CD74 leads to a signaling cascade resulting in cell survival. Thus, CD74 is a survival receptor in health and disease. 26 Jul 2010 at 11:00pm Computed tomographic colonography, also known as virtual colonoscopy, is not cost-effective if reimbursed at the same rate as colonoscopy, according to a new study. 20 Jul 2010 at 11:00pm A recent questionnaire submitted to a group of patients at one of the nation's largest general hospitals suggests that a significant number of patients, who have previously refused colorectal cancer screening, are willing to undergo computed tomography colonography, but not willing to pay for the exam themselves when not covered by insurance, according to a study. 20 Jul 2010 at 10:00am Researchers have found that combining novel optical technologies with a common colon cancer screening test may allow doctors to more accurately detect the presence of colon cancer, particularly in women. The study combined a polarization-gating optical probe alongside traditional flexible sigmoidoscopy to measure the early increase in blood supply in rectal tissue as a marker for colon cancer. 18 Jul 2010 at 1:00pm New recommendations on the use of the drug cetuximab have been issued after officials halted enrollment in a phase III clinical trial in patients with spread of colon cancer into regional lymph nodes whose tumors had been surgically removed. ongoing analysis during the clinical trial found that patients receiving the combination therapy had no significant improvement in survival compared to standard therapy. 14 Jul 2010 at 11:00pm Epidemiologists have presented information on survival of nine types of cancer in Spain and have compared it with other European countries. At five years from diagnosis, the lowest survival rate is observed in lung cancer (less than 11 percent), and the highest in testicular cancer (95 percent). Cancer survival in Spain is at the European average. |
1 Sep 2010 at 2:00am Researchers at the Faculty of Health Sciences have succeeded in decoding the genetic key that gives particular intestinal cells their identity. With this knowledge of the complex network of genes the researchers now hope to stop colon cancer by activating special anti-cancer genes. Colon sloughs lining The intestines have to work properly if we are to benefit from the food we eat... 26 Aug 2010 at 6:00am Responding to the interim decision by NICE not to recommend bevacizumab (Avastin) as a treatment for metastic colorectal cancer, Mike Hobday, Head of Policy at Macmillan Cancer Support, said: 'We think this is devastating news for cancer patients with metastic colorectal cancer, especially as this drug could have a significant impact on peoples' quality of life... 25 Aug 2010 at 3:00am NICE is issuing a second consultation document as part of its appraisal of bevacizumab (Avastin) in combination with chemotherapy (oxaliplatin and either 5-fluorouracil or capecitabine) for treating metastatic colorectal cancer. This second draft of the guidance does not recommend bevacizumab for this indication. This draft guidance has been issued for consultation... 23 Aug 2010 at 10:00am A new study published in a leading journal reports that rectal cancer appears to be rising among Americans under the age of 40, while colon cancer rates have remained steady for several decades; the study says more effort should go into diagnosing rectal cancer in young people... 20 Aug 2010 at 6:00am Although the medical community has already accepted that colorectal cancer (CRC) screening is cost effective and saves lives, researchers have found that computed tomography colonography (CTC or virtual colonoscopy) not only identifies CRC but also doubles the yield of identifying significant early extracolonic (outside the colon) lesions, resulting in lives saved, according to... 20 Aug 2010 at 6:00am Black patients die from colorectal cancer at much higher rates than whites do and new research points to unequal health care as the cause. While deaths from colorectal cancer have declined over the past 40 years, the declines have been uneven, said lead author Samir Soneji, Ph.D., of the Robert Wood Johnson Health and Society Scholars Program at the University of Pennsylvania... 20 Aug 2010 at 5:00am According to Millennium Research Group (MRG), the global authority on medical technology market intelligence, new coverage instituted under the Patient Protection and Affordable Care Act of 2010 will remove the financial disincentives associated with colorectal cancer screening for a large segment of the US population... 14 Aug 2010 at 3:00am Viatronix Incorporated, a Stony Brook, New York, based company announced the release of the latest version of its leading edge V3D-Colon software with the option to have the industry's first FDA 510(k) approved colon CAD, VeraLook™ by iCAD... 9 Aug 2010 at 3:00am Health Affairs: Little Evidence Of Correlation Between Growth In Health Care Spending And Reduced Mortality -This study examines differences in hospital mortality and cost between 2000 and 2004 for patients at 122 U.S... 7 Aug 2010 at 2:00am A new study from researchers in Italy has found that a split-dosage schedule of bowel (colon) preparation is the most effective method for bowel cleansing before colonoscopy. Colonoscopies performed within six to eight hours of the end of preparation were associated with significantly better cleansing than those performed more than eight hours after the end of preparation... 6 Aug 2010 at 5:00am The link between Hormone Replacement Therapy (HRT) and reduced risk of distal large bowel cancer in women; a promising combination antibiotic therapy for ulcerative colitis patients; and the high-rate of alcoholic liver disease mortality, are among the scientific findings featured in the August issue of The American Journal of Gastroenterology... 6 Aug 2010 at 4:00am A recent questionnaire submitted to a group of patients at one of the nation's largest general hospitals suggests that a significant number of patients, who have previously refused colorectal cancer screening, are willing to undergo computed tomography colonography (CTC) (or virtual colonoscopy), but not willing to pay for the exam themselves when not covered by insurance, acco... 5 Aug 2010 at 3:00am Anemia, a common blood disorder characterized by low hemoglobin levels, has long been associated with those suffering from colorectal cancer. But researchers at Tel Aviv University have discovered that, more than a symptom of active disease, low hemoglobin levels can actually indicate a potential for colon cancer years before it's diagnosed... 3 Aug 2010 at 5:00am An experimental vaccine based on a virus that causes encephalitis in the wild appears to block tumor growth in some cases of advanced cancer, according to researchers at Duke University Medical Center. Scientists say the vaccine is able to stimulate an immune response, even in the face of profound immune system suppression, a condition most patients with advanced cancer experience... 3 Aug 2010 at 5:00am A new analysis from Canada has found that cancer patients from poorer communities have a greater chance of dying prematurely than individuals from more affluent backgrounds even though cancer stage at time of diagnosis is similar across socioeconomic groups... |
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