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Colon Cancer News
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6 Oct 2008 at 4:01pm AP - Most people over 75 should stop getting routine colon cancer tests, according to a government health task force that also rejected the latest X-ray screening technology. 1 Oct 2008 at 10:46pm HealthDay - TUESDAY, Sept. 30 (HealthDay News) -- Researchers have uncovered a genetic link between obesity and the risk for colon cancer. The discovery could lead to greater accuracy in predicting who is at risk for the disease, experts say. 1 Oct 2008 at 3:50am Reuters - A gene related to a hormone secreted by the body's fat cells may lower the risk of colon cancer, a discovery that could reassure people with a family history of the disease, researchers said on Tuesday. 30 Sep 2008 at 11:18pm Reuters - Vitamin C supplements may undercut the effectiveness of cancer drugs including Novartis' Gleevec, a U.S. study published on Wednesday showed. 30 Sep 2008 at 4:42pm AFP - The discovery of a genetic link between obesity and colon cancer may pave the way for more effective screening tests for the disease, according to a study published Tuesday. 29 Sep 2008 at 1:48pm Reuters - There has been a substantial increase in the number of colorectal cancer screening tests conducted in older Americans, a new study shows. 24 Sep 2008 at 7:00pm American Cancer Society - Virtual colonoscopy, or computed tomographic (CT) colonography, is about as effective as traditional colonoscopy in finding colorectal cancer and large polyps, according to results from a large clinical trial comparing the two tests published in The New England Journal of Medicine. The study confirms results from smaller trials. 23 Sep 2008 at 10:47pm HealthDay - TUESDAY, Sept. 23 (HealthDay News) -- Black people undergoing colon cancer screening are more likely to have large precancerous polyps than are whites. 23 Sep 2008 at 3:09pm Reuters - Blacks are more likely than whites to have large colon polyps, and their tumors tend to be located higher in the colon where they are harder to detect, U.S. researchers said on Tuesday. 22 Sep 2008 at 10:46pm HealthDay - MONDAY, Sept. 22 (HealthDay News) -- A more intense but briefer course of radiation therapy is equally effective as the traditional longer course for certain breast cancer patients, Canadian researchers report. |
6 Oct 2008 at 4:37pm ... deal that would expand its pipeline of cancer treatments. New York-based ImClone had previously rejected ... cancer drugs include Erbitux, a treatment for colorectal and head and neck cancers, the lung ... 6 Oct 2008 at 4:31pm ... less tobacco exposure than men to increase colon cancer risk Orlando, FL October 6, 2008 While ... to have a significant increased risk for colorectal cancer, according to new research presented at ... 6 Oct 2008 at 4:31pm ... effectiveness of colonoscopy in detecting and removing pre-cancerous polyps, particularly tiny, flat, potentially pre-cancerous growths ... tiny, flat, potentially pre-cancerous growths in the colon known as "sessile serrated adenomas." Dr. Brindusa ... 6 Oct 2008 at 4:23pm ... American College of Gastroenterology, metabolic syndrome patients had a 75 percent higher risk of colorectal cancer compared to those without metabolic syndrome. Dr. Donald Garrow and Dr. Mark Delegge of ... 6 Oct 2008 at 4:17pm ... for Avastin-Tarceva combination study in advanced lung cancer Phase III data shows evidence of potential ... first-line treatment in patients with metastatic colorectal cancer (CRC) * June 2006 (US) ... 6 Oct 2008 at 4:16pm ... in a deal that would expand Lilly's cancer treatment pipeline a few years before several ... deal will add Erbitux, a treatment for colorectal and head and neck cancers, to Lilly's ... 6 Oct 2008 at 4:13pm ... quarter of 2009. ImClone's sole marketed product is Erbitux, which is used to treat colorectal, lung and head and neck cancers. The product had sales of about $1.3 billion in 2007. ImClone also has other ... 6 Oct 2008 at 4:00pm ... the market open. "It's becoming like a cancer which is spreading all over the place." ... ImClone ( ), the biotech that produces colon cancer treatment Erbitux, for $6 billion. of ... 6 Oct 2008 at 3:56pm ... included serious infections, one case of tuberculosis and two patients on azathioprine alone developing colon cancer. "There's such a great need for improvement" over standard treatments, said Dr. William Sandborn, ... 6 Oct 2008 at 3:56pm ... October 6, 2008 A screening program for colon cancer in patients starting ten years prior to ... older, their risk of developing polyps and colorectal cancer increases. Current guidelines recommend a screening ... 6 Oct 2008 at 3:56pm ... clinical trial of picoplatin, the Company's lead platform product candidate, in small cell lung cancer; the ongoing Phase 2 trials of picoplatin in colorectal and prostate cancers; and the ongoing Phase 1 trial of oral picoplatin through completion. ... 6 Oct 2008 at 3:56pm ... the potential to improve the detection of colorectal polyps and flat lesions during colonoscopy. The ... colonoscopy as the preferred strategy for colorectal cancer screening because of its remarkable sensitivity in ... Retroscope Device Boosts Polyp Detection in the Colon Researchers found that the retroscope, when combined ... 6 Oct 2008 at 3:52pm ... included serious infections, one case of tuberculosis and two patients on azathioprine alone developing colon cancer. "There's such a great need for improvement" over standard treatments, said Dr. William Sandborn, ... 6 Oct 2008 at 3:51pm ... deal that would expand its pipeline of cancer treatments. New York-based ImClone had previously rejected ... cancer drugs include Erbitux, a treatment for colorectal and head and neck cancers, the lung ... 6 Oct 2008 at 3:37pm ... and REMICADE with azathioprine, respectively. That includes 2 patients receiving azathioprine monotherapy who developed colon cancer, one patient receiving azathioprine monotherapy who died following a colectomy and one patient receiving ... |
by News-Medical News Feed 6 Oct 2008 at 4:17pm While smoking poses a health threat to both men and women, women require less tobacco exposure than men to have a significant increased risk for colorectal cancer, according to new research presented at the 73rd Annual ACG Scientific Meeting in Orlando. (Source: News-Medical News Feed) MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed. by AP Top Health News 6 Oct 2008 at 3:01pm PHILADELPHIA (AP) -- Most people over 75 should stop getting routine colon cancer tests, according to a government health task force that also rejected the latest X-ray screening technology.... (Source: AP Top Health News) by Huliq Health News 6 Oct 2008 at 11:10am While smoking poses a health threat to both men and women, women require less tobacco exposure than men to have a significant increased risk for colorectal cancer, according to new research presented at the 73rd Annual ACG Scientific Meeting in Orlando. (Source: Huliq Health News) by Huliq Health News 6 Oct 2008 at 11:08am New research presented at the American College of Gastroenterology's 73rd Annual Scientific Meeting in Orlando emphasizes the importance of adequate bowel preparation prior to colonoscopy, and highlights the remarkable effectiveness of colonoscopy in detecting and removing pre-cancerous polyps, particularly tiny, flat, potentially pre-cancerous growths in the colon known as "sessile serrated adenomas." (Source: Huliq Health News) by Huliq Health News 6 Oct 2008 at 10:23am In a large U.S. population-based study presented at the 73rd Annual Scientific Meeting of the American College of Gastroenterology, metabolic syndrome patients had a 75 percent higher risk of colorectal cancer compared to those without metabolic syndrome. (Source: Huliq Health News) by Huliq Health News 6 Oct 2008 at 10:20am A screening program for colon cancer in patients starting ten years prior to Medicare eligibility, at age 55 instead of Medicare's 65, would save at least two dollars for every dollar spent, according to a new study presented at the American College of Gastroenterology's 73rd Annual Scientific Meeting in Orlando. (Source: Huliq Health News) MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed. by The Saudi Journal of Gastroenterology 6 Oct 2008 at 8:01am Ibrahim Ezzeldin M, Zeeneldin Ahmed A, El-Khodary Tawfik R, Al-Gahmi Aboelkhair M, Bin Sadiq Bakr MSaudi Journal of Gastroenterology 2008 14(4):178-182<b>Background/Aims:</b> The crude frequency of colorectal cancer (CRC) is second to breast cancer in the Kingdom of Saudi Arabia (KSA). To assess the future burden of CRC in the country, we designed a model that takes into consideration the recent lifestyle pattern and the growth and aging of the population. <b> Methods:</b> We compared CRC statistics for KSA (using data from the National Cancer Registry) with that from the Surveillance, Epidemiology and End Results (SEER) databases of the United States of America (USA). We used the Joinpoint regression program to identify changes in secular trends, while the GLOBOCAN 2002 software was used to project future incidence and mortality. <b> Results:</b> Between 1994 and 2003, age-standardized rates (ASRs) for CRC in KSA almost doubled, as compared to a nonsignificant decline in USA. Between 2001 and 2003, while the annual percent change (APC) of CRC incidence in the USA showed a nonsignificant decrease in females, APC in Saudi females showed a nonsignificant rise of six percent. On the other hand, the rising incidence among Saudi males, during the years 1999 to 2003, was significant, with an APC of 20.5%. The projection model suggested that the incidence of CRC in KSA could increase fourfold in both genders by the year 2030. <b> Conclusions:</b> In KSA, the present and expected increase in CRC rates is alarming. Pragmatic recommendations to face that challenge are discussed. The present work could serve as a model to study other prevalent types of cancer, particularly in developing countries. (Source: The Saudi Journal of Gastroenterology) by The Saudi Journal of Gastroenterology 6 Oct 2008 at 8:01am Zubaidi AhmadSaudi Journal of Gastroenterology 2008 14(4):202-205The major concern in the case of cancer, whether one or in worse case more than one, is the extent of treatment required and the prognosis. This article reports three cases with two cancers: colorectal cancer and thyroid cancer, in the same patient at the same time. It also discusses the related clinical presentation and management of the cancers, and a review of literature has been presented. (Source: The Saudi Journal of Gastroenterology) by Inpharma 6 Oct 2008 at 1:01am (Source: Inpharma) by NaturalNews.com 6 Oct 2008 at 1:00am (NaturalNews) Recent research suggests that the antioxidant resveratrol, which naturally occurs in grape skins, can weaken pancreatic cancer cells and increase their vulnerability to chemotherapy."Resveratrol seems to have a therapeutic gain by making tumor cells more sensitive to radiation and making normal tissue less sensitive," said lead researcher Paul Okunieff, chief of radiation oncology at the University of Rochester Medical Center.In a study published in the journal Advances in Experimental Medicine and Biology,Okunieff and colleagues treated a group of pancreatic cancer cells with 50 mg of resveratrol, then iodized them to simulate the action of chemotherapy. Another group of cancer cells was iodized without undergoing any resveratrol treatment.Pancreatic cancer has long been known to be particularly resistant to chemotherapy. The researchers discovered that because the pancreas is continually producing digestive enzymes and pumping them into the duodenum, these enzymes actually flush away chemotherapy chemicals before they can have much impact.But in pancreatic cancer cells that had been treated with resveratrol, the cell membrane proteins responsible for this flushing had their functioning hampered. In addition to becoming more sensitive to chemotherapy, the cells also became more likely to undergo programmed death (apoptosis) due to the increased production of reactive oxygen species.While the reason for the decreased pumping action was not clear, it may have been a side effect of yet a third observed effect of resveratrol treatment: The mitochondria of the cancer cells was damaged, with its membranes depolarized. Because mitochondria are the energy source of the cell, damaged mitochondria hampers the cell's general ability to function, including its ability to flush out chemotherapy drugs.As a naturally occurring ingredient of red wine, resveratrol has drawn much attention from researchers investigating whether it might be responsible for wine's well-documented health benefits. Like all antioxidants, resveratrol is known to remove free radicals from the blood. Free radicals are known to be linked with cancer, inflammation related to cardiovascular disease, and the effects of aging.But scientists are also hard at work uncovering resveratrol's more specific effects. Numerous studies have demonstrated that the chemical can extend the lifespan of simple organisms such as worms and yeast, and even complex animals like fish. In one 2003 study, short-lived fish dosed with resveratrol lived more than 50 percent longer than fish not treated with the antioxidant. In addition, these fish had better swimming and learning ability at the end of their lives than the control fish did.Other studies have shown that resveratrol protects plants from bacterial or fungal infection and makes HIV more susceptible to certain antiviral drugs. In cells infected with the influenza virus, resveratrol treatment reduced the virus' ability to reproduce by 90 percent over a period of 24 hours.Resveratrol has also been shown to improve treadmill endurance in mice, and even to neutralize the negative effects of a high-fat diet. Mice fed a high-fat diet supplemented with 22 mg/kg of resveratrol had a 30 percent lower chance of dying when compared with mice eating only an unsupplemented high fat diet. This was approximately the same risk of death as mice eating a normal, non-high-fat diet.Finally, a number of studies have suggested that the antioxidant has anti-cancer benefits, from preventing the development of skin cancer in mice exposed to ultraviolet radiation to reducing the risk of esophageal or colorectal tumors in mice and rats exposed to carcinogens. It has also been shown to induce apoptosis in human fat cells under certain specific circumstances."Antioxidant research is very active and very seductive right now," Okunieff said. "The challenge lies in finding the right concentration and how it works inside the cell."The highest concentrations of resveratrol are found in grape skins. Peanuts contain about half as much resveratrol as grapes, while blueberries and bilberries contain only about 10 percent as much.While the resveratrol content of wine varies widely depending on the variety of grape, when and where it was grown, and how long it was fermented, the high level tends to be 30 mg per ml. This is lower than the dose used in the current study. But Okunieff said that higher doses should be safe as long as they are taken under a doctor's supervision."While additional studies are needed, this research indicated that resveratrol has a promising future as part of the treatment for cancer," he said.Approximately 33,000 new cases of pancreatic cancer are diagnosed in the United States every year. Patients have a very low rate of survival, in part due to the disease's resistance to chemotherapy. (Source: NaturalNews.com) MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed. by Medscape Hematology-Oncology Headlines 5 Oct 2008 at 8:21pm In this video blog, Dr. John Marshall observes that despite unexpected negative results in the PACCE and CAIRO2 trials, dual antibody therapy may yet play a role in colorectal cancer. Medscape Hematology-Oncology (Source: Medscape Hematology-Oncology Headlines) by PharmacoEconomics & Outcomes News 4 Oct 2008 at 5:17am Page: 5 (Source: PharmacoEconomics & Outcomes News) by Cancercompass News: Colorectal Cancer 4 Oct 2008 at 2:07am One of the most hotly debated topics in health care is how often to screen for different cancers. Current guidelines for colon cancer say it's okay to wait for ten years between the screenings, known in the medical world as colonoscopies. Some medical professionals and patients are calling for a change in that schedule, but, as Rose Hoban reports, a new study indicates that it is a reasonable guideline. To do a colonoscopy, doctors insert a flexible probe with a very small camera into the patient's colon to examine the intestinal wall. An independent panel of experts in primary care and disease prevention has recommended that the procedure be done every ten years. But some doctors and patients have insisted on more... (Source: Cancercompass News: Colorectal Cancer) by Nature Signaling Update 4 Oct 2008 at 1:36am CDK8 and E2F1 have antagonistic roles in beta-catenin-mediated transcription. (Source: Nature Signaling Update) MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed. by MedPage Today Primary Care 3 Oct 2008 at 9:46am EVANSTON, Ill. (MedPage Today) -- Even if the colonoscope comes up empty, an investigative endoscope that measures predysplastic epithelial microvascular blood content may one day score paydirt in colon cancer screening, researchers here said. (Source: MedPage Today Primary Care) |
6 Oct 2008 at 4:00pm While smoking poses a health threat to both men and women, women require less tobacco exposure than men to have a significant increased risk for colorectal cancer, according to new research. In a separate analysis, researchers found smoking may increase the risk of pancreatic cancer precursor lesions, particularly in patients with a strong family history of the disease. 5 Oct 2008 at 11:00pm New research emphasizes the importance of adequate bowel preparation prior to colonoscopy, and highlights the remarkable effectiveness of colonoscopy in detecting and removing pre-cancerous polyps, particularly tiny, flat, potentially pre-cancerous growths in the colon known as "sessile serrated adenomas." 5 Oct 2008 at 11:00pm A screening program for colon cancer in patients starting ten years prior to Medicare eligibility, at age 55 instead of Medicare's 65, would save at least two dollars for every dollar spent, according to a new study. 5 Oct 2008 at 11:00pm Two new studies highlight new technologies with the potential to improve the detection of colorectal polyps and flat lesions during colonoscopy. 3 Oct 2008 at 4:00am Researchers have discovered that fiber optic technology can for the very first time effectively measure blood levels in the colonic lining (mucosa) in humans, thus having potential applications for analyzing risk of colon cancer. The study used fiber optic technology to map microvascular blood content in patients during colonoscopy. The results provide the first indication that the early increase in blood supply is detectable in humans. 2 Oct 2008 at 1:00pm Scientists investigating a molecule known to play a key role in causing colon cancer have made a series of ground-breaking discoveries that could have major implications for future treatment of the disease. 1 Oct 2008 at 11:00pm Patients who undergo a complete negative colonoscopy have a reduced incidence of colorectal cancer. 1 Oct 2008 at 7:00pm It has already been proven that obesity is influenced by genetics, and colon cancer is influenced by genetics. A new study makes a three-way scientific connection between genetic variation, obesity and colon cancer risk. 1 Oct 2008 at 7:00pm A surgical technique not traditionally used in advanced abdominal cancer may be a viable treatment option for some patients previously thought to be untreatable, offering the real possibility of extending survival for those patients. 30 Sep 2008 at 1:00am What allows cancer cells to divide uncontrolled? The cellular oncogenes and tumor suppressor genes are analogous to the accelerator and brake pedals in a car. If an oncogene is permanently active, similar to a stuck accelerator in a car, cells divide without restraints and a tumor develops. 29 Sep 2008 at 11:00pm Young adults without a family history of bowel disease are unlikely to develop adenomas, the colorectal polyps most likely to lead to cancer, according to new research. The finding supports current cancer screening guidelines recommending adults in general undergo screening colonoscopies starting at age 50. 29 Sep 2008 at 7:00pm Compared with white patients, black patients undergoing screening colonoscopy have a higher prevalence of colon polyps. 23 Sep 2008 at 1:00am CT colonography, known as virtual colonoscopy, is as accurate at screening for colorectal cancers and pre-cancerous polyps as conventional colonoscopy, the current screening standard, according to the National CT Colonography Trial, a nationwide multi-center study that included the San Francisco VA Medical Center. 22 Sep 2008 at 11:00pm Scientists from China have isolated CD44+CD24+ subpopulation cells which have properties of tumor stem cells. Because cancer stem cells are thought to be responsible for tumor initiation, it may be a very promising target for new drug developments. 22 Sep 2008 at 10:00am Normal gut bacteria are thought to be involved in colon cancer but the exact mechanisms have remained unknown. Now, scientists have discovered that a molecule produced by a common gut bacterium activates signalling pathways that are associated with cancer cells. The research, published in the Journal of Medical Microbiology, sheds light on the way gut bacteria can cause colon cancer. |
3 Oct 2008 at 8:00am Amgen Belgium announces the availability of Vectibix® (panitumumab), the first fully human anti-EGFR monoclonal antibody indicated as monotherapy for the treatment of patients with epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer (mCRC) with non-mutated (wild-type) KRASgene after failure of fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy protocols. 3 Oct 2008 at 7:00am Incidence reduction in the proximal colon differs in magnitude and timing Patients who undergo a complete negative colonoscopy have a reduced incidence of colorectal cancer, confirms a study published in Clinical Gastroenterology and Hepatology. However, in the proximal colon, the incidence reduction of colorectal cancer following complete negative colonoscopy differs in magnitude and timing. 2 Oct 2008 at 8:00am Colectomy is a surgical procedure to remove all or part of the individual's colon. Also called the large intestine, the colon is a long tubelike organ at the end of the digestive system. A new feature on Mayo Clinic.com highlights the various types of colectomy operations. 2 Oct 2008 at 6:00am Researchers at NorthShore University HealthSystem (NorthShore) and Northwestern University have discovered that fiber optic technology can for the very first time effectively measure blood levels in the colonic lining (mucosa) in humans, thus having potential applications for analyzing risk of colon cancer. The study appears in the October 2008 issue of Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. 2 Oct 2008 at 5:00am Variation of a gene for a protein hormone that is secreted by fat cells is associated with a decreased colorectal cancer risk, according to a study in the October 1 issue of JAMA. Several studies have shown an association between obesity and the risk of colorectal cancer, according to background information in the article. Adiponectin is a hormone secreted by fat tissue, and serum levels of adiponectin are inversely correlated with obesity and high levels of insulin. 2 Oct 2008 at 2:00am DNA Direct, Inc. announced that the company will offer ColoSure(TM), a state of the art, safe, simple, and convenient test to screen for colon cancer -- the second leading cause of cancer-related deaths in the United States. ColoSure tests a single stool sample for a DNA marker associated with colorectal cancer, and may be ordered through DNA Direct's website at http://www.dnadirect.com. 1 Oct 2008 at 5:00am Research out of Wake Forest University School of Medicine suggests that a surgical technique not traditionally used in advanced abdominal cancer may be a viable treatment option for some patients previously thought to be untreatable, offering the real possibility of extending survival for those patients. 1 Oct 2008 at 5:00am Scientists investigating a molecule known to play a key role in causing colon cancer have made a series of ground-breaking discoveries that could have major implications for future treatment of the disease, responsible for 655,000 deaths worldwide per year. Their findings are published in the journal Cancer Research, today (Wednesday 1 October 2008). 1 Oct 2008 at 4:00am Young adults without a family history of bowel disease are unlikely to develop adenomas, the colorectal polyps most likely to lead to cancer, according to new research directed by scientists at the Johns Hopkins Kimmel Cancer Center. The finding supports current cancer screening guidelines recommending adults in general undergo screening colonoscopies starting at age 50. 1 Oct 2008 at 2:00am A new study published in the October 1 issue of JAMA reports that decreased colorectal cancer risk is linked to variation of a gene for a protein hormone that is secreted by fat cells. Previous research has pointed towards a link between colorectal cancer risk and obesity. Serum levels of adiponectin - a hormone secreted by fat tissue - are inversely related with obesity and high levels of insulin. 30 Sep 2008 at 7:00am ONI BioPharma Inc. (AMEX: ONI) announced that it has entered a Collaboration Agreement with a major international diagnostics company regarding ONI's unique biomarkers for early, middle and late stage colorectal cancer. Terms of the agreement have not been disclosed. ONI BioPharma scientists used its dynamic diagnostic platform, PCMAT, to discover proteins that are specifically expressed when healthy bowel cells become cancerous. 28 Sep 2008 at 1:00pm Transcriptional silencing of tumor suppressor genes by hypermethylation of CpG islands located in the promoter region is very common in human colorectal cancer. Dietary folate/vitamin B12 intake and MTHFR C677T genotype was suggested to protect against colorectal cancer. However, only a few studies have addressed the joint effects of circulating levels of folate/vitamin B12 and the MTHFR C677T genotype on the risk of epigenetic inactivation of specific tumor suppressor genes in CRC patients. 28 Sep 2008 at 12:00pm Ellagic acid was previousely shown to have anticarcinogenic, antioxidant and antifibrosis properties. The anticarcinogenic effect of ellagic acid was shown in several types of cancers including skin, esophageal, and colon cancers. However the mechanisms mediating anti-cancer effect of ellagic acid, in general, remain unknown. A research article published on 21 June 2008, in the World Journal of Gastroenterology addresses this question. The research team led by Dr. 26 Sep 2008 at 6:00am Global Insight's Senior Analyst/Oncology Gustav Ando's note on NICE's rejection of cancer drug Erbitux for NHS use. "In another setback for patients in the U.K., an important new colorectal cancer treatment called Erbitux has been deemed too expensive to become readily available on the NHS. 26 Sep 2008 at 2:00am DiagnoCure Inc. (TSX: CUR), a life sciences company commercializing high-value cancer diagnostic tests and delivering laboratory services, announced that its Guanylyl Cyclase C (GCC) marker for identifying colorectal cancer cells is being featured at two scientific meetings this month. |
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