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Preventing Osteoarthritis

Osteoarthritis is a degenerative form of arthritis. The joints in the body are composed of bone, which are covered with a smooth layer of cartilage. If you have a family history of osteoarthritis then you have a higher chance of developing the disease yourself. Besides genetic predisposition, osteoarthritis can be present in those who are overweight or those who routinely put stress on the particular joint. Injury is also a culprit.

Osteoarthritis affects the joints in the body, most commonly the spine, hips, knees, feet and hands. It is caused by the wearing down of cartilage between these joints, causing bones to rub together. This causes discomfort and a decrease in mobility to the area. Symptoms of osteoarthritis are generally limited to the joint involved. Patients usually experience pain when they use the joint and the symptoms go away with rest. Patients may have some stiffness, when they first use a joint. If the arthritis is severe, patients may lose functional capacity in the joint that has osteoarthritis.

Osteoarthritis is the most common form of arthritis, affecting 21 million people in the United States. It can be caused by a number of factors. While it is more frequently found in those over 45, it can occur in younger people. Under 45, men are more likely to develop the disease than women, while over 45 women are more likely to develop it than men.

Fortunately, there are ways to prevent the onset of the disease, and it's easier than you think. It's about taking care of your body, which hopefully you're doing already as good health is the key to combating any form of disease, as well as education.

If you are overweight you are far more likely to develop osteoarthritis than someone who isn't. This is because the extra weight puts unnecessary stress on the joints. Keeping in shape also helps to prevent many other diseases, such as heart disease.

Keep fit, not only to keep your weight in healthy range but also to work your joints. Aerobic exercises that work as much of your body are especially important; they revitalize your circulatory system and keep your heart rate up, as well as keep your joints limber. Make sure not to over exert yourself, especially if you feel pain in a joint, as this may only cause to exacerbate the condition you are trying to prevent. Discuss with your doctor what kinds of exercises are best for you. Osteoarthritis in the hands is the most genetically predispositioned form of the disease, so if you are at risk ask your doctor if there is anything you can do.

Injury to the joints can also cause the onset of osteoarthritis. Be sure to wear protective gear, like wrist guards for instance, when deemed necessary.

There have been some foods and supplements that have been reported to decrease your chances of getting the disease. While some initial results have proved encouraging, studies are still continuing for conclusive results. None of the supplements have been reported to carry side effects though, and are part of a healthy lifestyle.

An anti-inflammatory is just what you're looking for. Anti-inflammatory properties can be found in Omega-3 fatty acids, which are found in fatty fish like salmon or albacore tuna. Since our North American diet is severely lacking in fish on a regular basis, try an Omega-3 fatty acid supplement such as Omega Daily.

Early detection is important. If you feel a recurring pain in your joints, or a stiffness that won't go away, talk to your doctor. He or she can help you find the best way to deal with the pain.

Rheumatoid Arthritis

Rheumatoid Arthritis, or RA, is an autoimmune disorder, causing your immune system to attack the joints, causing a painful inflammation. Unlike other forms of arthritis like osteoarthritis, RA also attacks the organs like the heart, eyes and lungs. Of the 100+ forms of arthritis, this is one of the most debilitating varieties.

Rheumatoid Arthritis affects 1 out of 100 North Americans, or 2.1 million people, and women are three times more likely to get the disease than men. The cause of RA is unknown, but a popular theory points to the disease being infectious as those who have close friends or family with the disorder are more likely to develop it themselves. Susceptibility to the disease may also be an inherited trait as well.

Early detection is vital in treating RA because the most damage is done within the first two years, with 75% of the damage occurring within the first five years. While there is no cure or preventative measure for rheumatoid arthritis, there are a number of treatments to alleviate symptoms. Each type of drug includes its own side effects- make sure that you are informed about the medication you are taking, and report any side effects to your doctor.

Non-Steroidal Anti-Inflammatory Drugs, or NSAIDs, reduce the pain and swelling of the joints. Many can be had without a prescription, like acetylsalicylic acid and ibuprofen. In more severe cases your doctor can prescribe a stronger NSAID. Omega-3, found in fatty fish, also works to shorten the period of stiffness in the morning, one of the major symptoms of rheumatoid arthritis. Add salmon or albacore tuna to your diet, or try an Omega-3 supplement like Omega Daily.

Disease-Modifying Anti-Rheumatic Drugs, known as DMARDs, are slow-acting and may take weeks to take effect. While NSAIDs are effective in relieving pain short term, DMARDs are a long term treatment meant to reduce damage to the joint and bone. Methotrexate is the most widely used DMARD.

There are a number of things you can do yourself to make living with the disease easier. While it is tempting to put as little exertion on your sore joints as possible, keeping active is essential to enjoying life with rheumatoid arthritis. This is for a number of reasons. The first is that regular exercise strengthens the muscles around the joint and increases flexibility. Try low-impact activities, like swimming. Try not to partake in any activities that involve too much exertion, which causes more harm than good. Use heat and cold to your advantage, easing pain. Heat should be applied only when the joint is not inflamed, and preferably in the form of a bath or hot shower. Use cold packs on the inflamed joint directly or after strenuous use of the joint.

Arthritis News
Fat limbs linked to disability in arthritis (Reuters)
3 Oct 2008 at 12:42pm
Reuters - People with rheumatoid arthritis (RA) who have more fat on their arms and legs suffer more disability from the disease, according to the first study to look at how fat and lean mass affect body function in RA patients.

Genes pinpoint people at risk for gout: study (Reuters)
3 Oct 2008 at 11:30am
Reuters - Scientists have pinpointed three genes related to the high blood levels of uric acid that cause gout in a step that could help identify people at special risk for this common and painful type of arthritis.

Resistance Training Boosts Mobility in Knee Arthritis Patients (HealthDay)
2 Oct 2008 at 10:46pm
HealthDay - THURSDAY, Oct. 2 (HealthDay News) -- Resistance training improves muscle strength and physical functioning while decreasing pain in many people with knee osteoarthritis, a new report says.

Body Fat, Muscle Distribution Linked to RA Disability (HealthDay)
2 Oct 2008 at 10:46pm
HealthDay - THURSDAY, Oct. 2 (HealthDay News) -- How fat and muscle are distributed throughout the body is one of the factors that contribute to limited mobility of people rheumatoid arthritis, a new study finds.

Rheumatoid arthritis tied to joint surgery in past (Reuters)
2 Oct 2008 at 12:21pm
Reuters - Before newer, more effective drugs became available for treating rheumatoid arthritis, more than half of patients with the condition required orthopedic surgery, including a joint replacement in many cases, Swedish researchers report.

Three Genes Raise Gout Risk (HealthDay)
1 Oct 2008 at 10:46pm
HealthDay - TUESDAY, Sept. 30(HealthDay News) -- Three genes may raise risks for painful gout by up to 40 times, researchers report.

Occupational Therapy Plus Exercise Benefits Osteoarthritis (HealthDay)
30 Sep 2008 at 10:46pm
HealthDay - TUESDAY, Sept. 30 (HealthDay News) -- Adding occupational therapy to a structured exercise program increases physical activity for most people who have hip and knee osteoarthritis, say researchers.

Popular Supplements Don't Work Against Arthritis: Study (HealthDay)
30 Sep 2008 at 10:46pm
HealthDay - TUESDAY, Sept. 30 (HealthDay News) -- The popular supplements glucosamine and chondroitin are no better than a placebo at preventing cartilage loss in knees of people with the form of arthritis caused by wear and tear, a new study found.

Pain More a Cause of Arthritis Than a Symptom (HealthDay)
29 Sep 2008 at 10:46pm
HealthDay - MONDAY, Sept. 29 (HealthDay News) -- The pain caused by osteoarthritis may be as damaging as the disease itself, according to a new study.

Glucosamine and chondroitin don't slow arthritis (Reuters)
29 Sep 2008 at 3:26pm
Reuters - Two hugely popular supplements used to fight arthritis and joint pain, glucosamine and chondroitin sulfate, do not seem to work any better than placebo to slow the loss of knee cartilage in osteoarthritis, researchers reported on Monday.

PanGenetics To Initiate Clinical Study Of CD40 Antagonist Antibody In Psoriat...
6 Oct 2008 at 7:00am
PanGenetics B.V. announced today that the company has received formal regulatory approval to initiate clinical evaluation of the company's CD40 antagonist antibody, PG102. The multi-centre trial in Hungary and Serbia will recruit patients with active psoriatic arthritis, and is designed as a double blind, placebo controlled, single ascending dose study. The primary objective of the Phase I study is to evaluate the safety and tolerability of PG102.

Natural Compounds That Could Slow Blood Vessel Growth
6 Oct 2008 at 2:00am
Using computer models and live cell experiments, biomedical engineers at the Johns Hopkins University School of Medicine have discovered more than 100 human protein fragments that can slow or stop the growth of cells that make up new blood vessels.

Researchers Identify Genes Associated With Increased Gout Risk
4 Oct 2008 at 2:00am
A team of researchers from the United States and the Netherlands has identified mutations in three genes that are associated with high levels of uric acid in the blood, which is a risk factor for gout. The team developed a genetic risk score composed of the number of uric acid-increasing mutations that each person carries (0 to 6), which was associated with up to a 40-fold increased risk for developing gout when comparing persons at lowest and highest risk.

Repurposing Of Enbrel For Alzheimer's Disease
3 Oct 2008 at 5:00am
At Cambridge Healthtech Institute's Third Annual Drug Repositioning Summit on Monday, October 6 in Boston, the audience is scheduled to hear, as a Keynote Presentation, the story of how an individual physician has charted an entirely new course for a therapeutic which is already one of the most successful of all time.

Preclinical Findings Highlight Novel Approach To Maximizing DsiRNAs In Rheuma...
3 Oct 2008 at 3:00am
Dicerna Pharmaceuticals, Inc., a second generation RNA interference company developing novel therapeutics utilizing proprietary Dicer Substrate Technologyâ„¢, announced today a paper appearing in the advance online publication of Molecular Therapy which describes the therapeutic potential for Dicer-substrate small interfering RNAs (DsiRNAs) in the treatment of rheumatoid arthritis in a murine model of arthritis.

Arana Files IND For Lead Anti-Inflammatory Product ART621 In Rheumatoid Arthr...
1 Oct 2008 at 11:00am
Biotechnology company Arana Therapeutics Limited (ASX: AAH) announced it has submitted an Investigational New Drug application (IND) to the FDA (U.S. Food and Drug Administration) for the anti-inflammatory product ART621 in a rheumatoid arthritis (RA) indication. The IND includes a Phase II dose ranging study of ART621/221 in RA which is planned to be an international multi-centred trial of approximately 200 patients.

Follow-On Phase I Study For Novel Oral Anti-Inflammatory Drug Targeting Rheum...
1 Oct 2008 at 10:00am
VGX Pharmaceuticals, a biopharmaceutical company that is developing DNA vaccines for cancer and HIV and therapeutics for other diseases, announced today the results of a Phase I single ascending dose (SAD) study that demonstrated that its lead anti-inflammatory compound, VGX-1027, was generally safe and well tolerated in humans. As a result, VGX Pharmaceuticals and VGX International, a Korean affiliate that is jointly developing VGX-1027, have commenced a multiple ascending dose (MAD) study.

Knee Arthritis Did Not Benefit From Supplements
1 Oct 2008 at 2:00am
US scientists found that the dietary supplements glucosamine and chondroitin sulfate were no more effective than placebo at slowing down the rate of cartilage loss in the knees of patients with osteoarthritis; however they also said the trial was probably too short and too small, and spoke more to scientists about how to conduct further research in this area than than to patients. The two-year multicenter study was the work of rheumatologist Dr Allen D.

Supplements No Better Than Placebo In Slowing Cartilage Loss In Knees Of Oste...
30 Sep 2008 at 4:00am
In a two-year multicenter study led by University of Utah doctors, the dietary supplements glucosamine and chondroitin sulfate performed no better than placebo in slowing the rate of cartilage loss in the knees of osteoarthritis patients. This was an ancillary study concurrently conducted on a subset of the patients who were enrolled in the prospective, randomized GAIT (Glucosamine/chondroitin Arthritis Intervention Trial).

Pain Is Not A Symptom Of Arthritis, Pain Causes Arthritis: New Study
30 Sep 2008 at 4:00am
Pain is more than a symptom of osteoarthritis, it is an inherent and damaging part of the disease itself, according to a study published today in journal Arthritis and Rheumatism. More specifically, the study revealed that pain signals originating in arthritic joints, and the biochemical processing of those signals as they reach the spinal cord, worsen and expand arthritis.

Occupational Therapy Gets People With Osteoarthritis Moving
29 Sep 2008 at 11:00am
Physical activity is the cornerstone of any healthy lifestyle - and especially for people with osteoarthritis as exercise helps maintain good joint health, manage their symptoms, and prevent functional decline. Osteoarthritis, however, often makes physical activity, such as exercise, and even performing daily activities, a challenge.

Working Environment Is One Cause Of Rheumatoid Arthritis
25 Sep 2008 at 3:00am
It has long been known that environmental factors play a part in the development of rheumatoid arthritis; smoking and drinking alcohol, along with heredity, are particularly instrumental in increasing the risk of the disease. Scientists at Karolinska Institutet have now produced results that suggest that working environment factors can also increase the chances of developing rheumatoid arthritis.

Chronic Hepatitis C Infection In A Patient With Bone Marrow Hypoplasia
24 Sep 2008 at 2:00pm
HCV is acquired by intravenous drug abuse, sexually or via blood transfusion (rare nowadays due to the effective screening of blood products before transfusion). HCV is known to cause chronic infection in 80% - 90% of the patients becoming infected. Patients present with varying degrees of altered liver function ranging from mild cirrhosis to necrosis (liver cell death).

Data Supports Safety Record Of ENBREL(R) As Continuous Therapy In Children An...
23 Sep 2008 at 3:00pm
Wyeth announced study results from last week's 15th Paediatric Rheumatology European Congress (PRES) in London which highlight the safety record of etanercept (ENBREL(R)) as a continuous therapy in children and adolescents with juvenile idiopathic arthritis (JIA).(1) The study was designed to evaluate the safety of ENBREL in children with polyarticular or systemic JIA.

Discovery Of New Drug Target For Inflammatory Disease By UC Davis Researchers
23 Sep 2008 at 7:00am
UC Davis researchers have defined a cellular process that promotes inflammation and, at the same time, found an important starting point for identifying and testing new drugs for diseases such as sepsis, rheumatoid arthritis, cardiovascular disease and some cancers.

Gout Tracked to Genes that Affect Urate Levels
30 Sep 2008 at 5:30pm
BETHESDA, Md. (MedPage Today) -- A genetic risk score based on three genes that influence serum levels of uric acid are associated with a 40-fold increased risk for gout, investigators here reported.

X-Ray Evidence Shows Popular Supplements Fail to Slow Knee Osteoarthritis
30 Sep 2008 at 1:59pm
SALT LAKE CITY (MedPage Today) -- Glucosamine and chondroitin sulfate, individually or in combination, were ineffective in reducing long-term radiographic progression of knee osteoarthritis, showed a large randomized trial.

RA Patient Treated With Rituximab Dies of PML
11 Sep 2008 at 2:40pm
ROCKVILLE, Md. (MedPage Today) -- A rheumatoid arthritis patient treated with rituximab (Rituxan) was diagnosed with progressive multifocal leukoencephalopathy (PML) 18 months after taking the last dose of the agent, and later died, the FDA and drugmakers announced today.

Herniated Disc Surgery Found Cost-Effective
11 Sep 2008 at 11:21am
HANOVER, N.H. (MedPage Today) -- For patients with a herniated disc, surgery proved a cost-effective alternative to nonsurgical treatment over the course of two years, an observational study found.

Stroke Risk Higher in RA Patients
5 Sep 2008 at 2:49pm
WICHITA, Kan. (MedPage Today) -- Patients with rheumatoid arthritis, particularly those with severe disease, have an increased risk of stroke, according to researchers here.

Ibuprofen Use Increases Cardiovascular Risk but Not for All Older Patients
5 Sep 2008 at 11:51am
BOSTON (MedPage Today) -- Ibuprofen use was associated with increased cardiovascular risk in several subgroups of older patients, but not in those with rheumatoid arthritis, researchers found.

FDA Demands Stronger Fungal Infection Warnings on TNF Blockers
4 Sep 2008 at 3:20pm
ROCKVILLE, Md. (MedPage Today) -- The FDA announced today that it will require makers of tumor necrosis factor-alpha (TNF) blockers to strengthen warnings about serious fungal infections, particularly histoplasmosis.

Adalimumab (Humira) Demonstrates Biologic Efficacy in Juvenile RA
20 Aug 2008 at 4:00pm
CINCINNATI (MedPage Today) -- Disease flares in children with polyarticular-course juvenile rheumatoid arthritis were significantly reduced by adalimumab (Humira) with or without methotrexate, researchers here reported.

Clinical Trial Said to Have Been Marketing in Disguise
18 Aug 2008 at 4:00pm
BELMONT, Mass. (MedPage Today) -- The ADVANTAGE trial comparing Merck's rofecoxib (Vioxx) with naproxen (Aleve) was designed and executed primarily for marketing purposes, said researchers here.

Frankincense Extract Said to Reduce Osteoarthritis Pain
29 Jul 2008 at 6:00pm
DAVIS, Calif. (MedPage Today) -- For patients with knee osteoarthritis, an extract of the Indian frankincense plant gave significant pain relief and reduced levels of a marker of joint pathology, researchers here said.

Biologics and Combinations Top Arthritis Recommendations
24 Jul 2008 at 5:26pm
ATLANTA (MedPage Today) -- Early, aggressive treatment of rheumatoid arthritis with biologic agents and potent drug combinations has moved front and center in the American College of Rheumatology practice guidelines.

Combo Drug Treatment Scores for Early Rheumatoid Arthritis
15 Jul 2008 at 5:30pm
LEEDS, England (MedPage Today) -- Combining methotrexate and etanercept (Enbrel) for early moderate-to-severe rheumatoid arthritis improved remission and progression rates within a year, a randomized trial found.

Abatacept (Orencia) Improved Arthritis in Kids, but Study Design Criticized
14 Jul 2008 at 5:07pm
GENOA, Italy (MedPage Today) -- Children with idiopathic arthritis unresponsive to other drugs improved on abatacept (Orencia) compared with those given a placebo, a randomized withdrawal trial found.

Outcomes Excellent for Joint Replacement in Older Adults
14 Jul 2008 at 3:00pm
BOSTON (MedPage Today) -- Older patients who had hip or knee replacement for severe osteoarthritis took several weeks to recover but had excellent long-term outcomes, a prospective study found.

Multitargeted Immune Therapy Scores Well for Severe Lupus Nephritis
2 Jul 2008 at 2:18pm
NANJING, China (MedPage Today) -- In patients with severe combined lupus nephritis, multitargeted immune therapy led to more than a six-fold increase in the rate of complete remissions compared with intravenous cyclophosphamide, investigators here reported.

Resistance Training Boosts Mobility in Knee Arthritis Patients
3 Oct 2008 at 2:00am
Title: Resistance Training Boosts Mobility in Knee Arthritis Patients
Category: Health News
Created: 10/3/2008 2:00:00 AM
Last Editorial Review: 10/3/2008

Body Fat, Muscle Distribution Linked to RA Disability
3 Oct 2008 at 2:00am
Title: Body Fat, Muscle Distribution Linked to RA Disability
Category: Health News
Created: 10/3/2008 2:00:00 AM
Last Editorial Review: 10/3/2008

Shoulder Bursitis
2 Oct 2008 at 2:00am
Title: Shoulder Bursitis
Category: Diseases and Conditions
Created: 12/31/1997
Last Editorial Review: 10/2/2008

Bursitis of the Knee
1 Oct 2008 at 2:00am
Title: Bursitis of the Knee
Category: Diseases and Conditions
Created: 12/31/1997
Last Editorial Review: 10/1/2008

MCTD vs. UCTD
1 Oct 2008 at 2:00am
Title: MCTD vs. UCTD
Category: Doctor's Views
Created: 4/19/2001
Last Editorial Review: 10/1/2008

Diabetes and Foot Problems
1 Oct 2008 at 2:00am
Title: Diabetes and Foot Problems
Category: Diseases and Conditions
Created: 1/31/2005 4:24:00 AM
Last Editorial Review: 10/1/2008

Occupational Therapy Plus Exercise Benefits Osteoarthritis
1 Oct 2008 at 2:00am
Title: Occupational Therapy Plus Exercise Benefits Osteoarthritis
Category: Health News
Created: 10/1/2008 2:00:00 AM
Last Editorial Review: 10/1/2008

Media Doesn't Often Mention Pharma Funding on Research
1 Oct 2008 at 2:00am
Title: Media Doesn't Often Mention Pharma Funding on Research
Category: Health News
Created: 10/1/2008 2:00:00 AM
Last Editorial Review: 10/1/2008

Three Genes Raise Gout Risk
1 Oct 2008 at 2:00am
Title: Three Genes Raise Gout Risk
Category: Health News
Created: 10/1/2008 2:00:00 AM
Last Editorial Review: 10/1/2008

Knee Arthritis: Supplements May Not Help
1 Oct 2008 at 2:00am
Title: Knee Arthritis: Supplements May Not Help
Category: Health News
Created: 10/1/2008
Last Editorial Review: 10/1/2008

2 New Gout Genes Discovered
1 Oct 2008 at 2:00am
Title: 2 New Gout Genes Discovered
Category: Health News
Created: 10/1/2008
Last Editorial Review: 10/1/2008

Headache
30 Sep 2008 at 2:00am
Title: Headache
Category: Diseases and Conditions
Created: 5/31/2002
Last Editorial Review: 9/30/2008

Follow-on phase i study for novel oral anti-inflammatory drug targeting rheum...
by Arthritis News From Medical News Today
1 Oct 2008 at 9:00am
VGX Pharmaceuticals, a biopharmaceutical company that is developing DNA vaccines for cancer and HIV and therapeutics for other diseases, announced today the results of a Phase I single ascending dose (SAD) study that demonstrated that its lead anti-inflammatory compound, VGX-1027, was generally safe and well tolerated in humans. As a result, VGX Pharmaceuticals and VGX International, a Korean affiliate that is jointly developing VGX-1027, have commenced a multiple ascending dose (MAD) study. (Source: Arthritis News From Medical News Today)

Working environment is one cause of rheumatoid arthritis
by Arthritis News From Medical News Today
25 Sep 2008 at 2:00am
It has long been known that environmental factors play a part in the development of rheumatoid arthritis; smoking and drinking alcohol, along with heredity, are particularly instrumental in increasing the risk of the disease. Scientists at Karolinska Institutet have now produced results that suggest that working environment factors can also increase the chances of developing rheumatoid arthritis. (Source: Arthritis News From Medical News Today)

Discovery of new drug target for inflammatory disease by uc davis researchers
by Arthritis News From Medical News Today
23 Sep 2008 at 6:00am
UC Davis researchers have defined a cellular process that promotes inflammation and, at the same time, found an important starting point for identifying and testing new drugs for diseases such as sepsis, rheumatoid arthritis, cardiovascular disease and some cancers. (Source: Arthritis News From Medical News Today)

Rheumatoid arthritis prevalence is lower among asians and higher among americ...
by Arthritis News From Medical News Today
23 Sep 2008 at 2:00am
Decision Resources, one of the world's leading research and advisory firms focusing on pharmaceutical and healthcare issues, finds that in the U.S. rheumatoid arthritis prevalence is lower among Asians and higher among American Indians, compared with the prevalence among Blacks and Whites. The new analytics tool entitled PatientFinder: Rheumatoid Arthritis also reveals that rheumatoid arthritis prevalence in the U.S. varies by how urban or rural the population is. (Source: Arthritis News From Medical News Today)

2008 world congress on osteoarthritis
by Arthritis News From Medical News Today
17 Sep 2008 at 3:00am
2008 World Congress on Osteoarthritis. September 18 - 21, 2008 Rome Marriott Park Hotel Rome, Italy. 2009 OARSI World Congress has an exciting programe featuring speakers from around the world. This year's opening-day session will feature plenary sessions devoted to a comprehensive overview of current clinical trials for osteoarthritis, outcomes, and the current exciting basic science that fuels the endeavor to make a difference in patients' lives. (Source: Arthritis News From Medical News Today)

Webcast presentation of results from phase 2 study of arcalyst(r) (rilonacept...
by Arthritis News From Medical News Today
4 Sep 2008 at 3:00am
Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN) announced that Dr. Leonard S. Schleifer, President and Chief Executive Officer of Regeneron, and other members of senior management will host a webcast conference call commencing at 8:30 a.m. Eastern Time on Wednesday, September 3, 2008. Dr. (Source: Arthritis News From Medical News Today)

Scanning for the early signs of osteoarthritis
by Arthritis News From Medical News Today
3 Sep 2008 at 3:00am
Many health problems can be effectively treated and managed if they are caught early enough. But until now, diagnosing the early stage of osteoarthritis - the often cripplingly painful disease that causes damage to the joints and is thought to affect around 8.5m Brits - has been tricky. That's because diagnosis currently relies on x-ray evidence and physical examination, both of which may not spot signs of the disease until it's in its later stages. (Source: Arthritis News From Medical News Today)

Pipex pharmaceuticals acquires late-stage oral phase ii candidate for rheumat...
by Arthritis News From Medical News Today
21 Aug 2008 at 1:00am
Pipex Pharmaceuticals, Inc. (AMEX: PP), a specialty pharmaceutical company developing innovative late-stage drug candidates for the treatment of central nervous system and autoimmune diseases, today announced that it has acquired an oral, once-daily candidate for the treatment of rheumatoid arthritis (RA) which has completed a 160 patient, multi-center, double-blind, randomized, placebo-controlled Phase II clinical trial for the treatment of rheumatoid arthritis (RA). (Source: Arthritis News From Medical News Today)

Inflammation and immunologic symposium explores new research in chronic diseases
by Arthritis News From Medical News Today
13 Aug 2008 at 2:00am
For the first time in the United States, more than 200 scientists from around the world will gather to explore research challenging conventional theories about immunology, inflammation and their link to acute and chronic diseases. The Damage Associated Molecular Pattern Molecules (DAMPs) and Alarmins Symposium will be held at the Hillman Cancer Center, 5115 Centre Ave., Pittsburgh, Aug. 30 through Sept. 2. (Source: Arthritis News From Medical News Today)

Key clinical studies of regeneron's arcalyst (rilonacept) for treatment of ca...
by Arthritis News From Medical News Today
12 Aug 2008 at 3:00am
Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN) announced the publication of the results of three studies which supported the U.S. Food and Drug Administration (FDA) regulatory submission for ARCALYST® (rilonacept) Injection for Subcutaneous Use for the treatment of Cryopyrin-Associated Periodic Syndromes (CAPS). Two studies were published in the August 2008 issue of Arthritis and Rheumatism, the flagship publication of the American College of Rheumatology. (Source: Arthritis News From Medical News Today)

B cells can act alone in autoimmune disease, yale researchers report
by Arthritis News From Medical News Today
7 Aug 2008 at 3:00am
B cells, the source of damaging autoantibodies, have long been thought to depend upon T cells for their activation and were not considered important in the initiation of autoimmune diseases like lupus or rheumatoid arthritis. In the Aug. 7 online issue of the journal of Immunity, Yale University researchers turn this paradigm on its head by showing that in systemic autoimmune diseases B cells can be activated the absence of T cells. (Source: Arthritis News From Medical News Today)

Scolr pharma, inc. submits abbreviated new drug application for a 12-hour cdt...
by Arthritis News From Medical News Today
7 Aug 2008 at 2:00am
Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that 89 percent of surveyed rheumatologists anticipate prescribing Roche/Chugai's Actemra, following the expected launch of the drug for rheumatoid arthritis in 2009. (Source: Arthritis News From Medical News Today)

Fda advisory committee recommends approval of actemra(r) (tocilizumab) for th...
by Arthritis News From Medical News Today
30 Jul 2008 at 3:00am
Roche announced that the Arthritis Advisory Committee of the U.S. Food and Drug Administration (FDA) by a near unanimous (10-1) vote recommended approval of ACTEMRA(R) (tocilizumab), a novel interleukin-6 (IL-6) receptor-inhibiting monoclonal antibody, for reducing the signs and symptoms in adults with moderate to severe rheumatoid arthritis (RA). (Source: Arthritis News From Medical News Today)

Roche comment on nice anti-tnf inhibitor sequencing fad
by Arthritis News From Medical News Today
23 Jul 2008 at 3:00am
Following the widespread media coverage regarding the NICE FAD on the sequencing of anti-TNF inhibitors, Roche want to reassure patients with rheumatoid arthritis and rheumatology health professionals that they will continue to benefit from access to effective treatment with MabThera (rituximab), following the use of one anti-TNF, for this debilitating disease. (Source: Arthritis News From Medical News Today)

Improved rheumatoid arthritis remission with combined therapy
by Arthritis News From Medical News Today
18 Jul 2008 at 1:00am
For patients with active, early stage, moderate-to-severe rheumatoid arthritis, a combination treatment with methotrexate and etanercept can improve remission and radiographic non-progression rates within one year in comparison with just methotrexate. Additionally, more patients are also able to remain employed. These conclusions are published in an article released early Online on July 16, 2008 in The Lancet. (Source: Arthritis News From Medical News Today)

New Finding May Improve Diagnosis of Juvenile Leukemia
6 Oct 2008 at 11:59am
An abnormal signaling pathway that appears to be highly specific to juvenile myelomonocytic leukemia could allow for more rapid and accurate diagnosis and targeted therapies.
Medscape Medical News

Black Patients Have Poorer Survival in Head and Neck Cancer
6 Oct 2008 at 1:00pm
A new analysis shows that race and socioeconomic status have a significant affect on patient survival in head and neck cancer, even after adjustment for other factors
Medscape Medical News

Genomewide Study of Ulcerative Colitis Identifies Variants Contributing to Di...
6 Oct 2008 at 2:43pm
The gene for interleukin 10, an immunosuppressive cytokine, plays a clear role in ulcerative colitis susceptibility.
Medscape Medical News

Simple Interventions Help Decrease Narcotic-Related Pediatric Adverse Drug Ev...
6 Oct 2008 at 4:00pm
A study shows that implementation of various simple interventions decreases narcotic-related adverse drug events in hospitalized children.
Medscape Medical News

Using a Fan During Sleep May Help Prevent Sudden Infant Death Syndrome
6 Oct 2008 at 4:00pm
A population-based case-control study shows that the incidence of sudden infant death syndrome may be reduced by using a fan in an infant's sleeping environment.
Medscape Medical News

Tiotropium Induces Long-Term Improvement in Lung Function, QOL in COPD Patients
6 Oct 2008 at 4:00pm
Tiotropium improves quality of life and multiple parameters of lung function but does not slow decline in forced expiratory volume in 1 second in patients with chronic obstructive pulmonary disease.
Medscape Medical News

Procalcitonin May Help Detect Serious Bacterial Infections in Febrile Infants
6 Oct 2008 at 4:00pm
In an observational study, use of procalcitonin was effective in detecting serious bacterial infections in young febrile infants, especially in detecting the most serious occult infections.
Medscape Medical News

Nearly Two Thirds of Revascularized Patients Have Asymptomatic Sleep Apnea
6 Oct 2008 at 9:56am
A randomized trial of continuous positive airway pressure in patients with coronary artery disease and obstructive sleep apnea reveals that an unexpectedly high percentage have no symptoms of daytime sleepiness.
Medscape Medical News

First Major Gene Reported for Autosomal Recessive Retinitis Pigmentosa
6 Oct 2008 at 10:34am
Independent mutations in a newly identified gene, EYS, are present in unrelated families with retinitis pigmentosa.
Medscape Medical News

Obese African American Women More Likely to Be Depressed
6 Oct 2008 at 9:40am
African American women who are obese are 41% more likely than their slimmer counterparts to be depressed, according to new research from the Centers for Disease Control and Prevention.
Medscape Medical News

Nocturnal Asthma Poorly Treated
6 Oct 2008 at 9:53am
Two surveys of nearly 35,000 adults with asthma show that almost all patients were awakened at least once a month by asthma symptoms, and three quarters were awakened at least once a week.
Medscape Medical News

Obama's Healthcare Plan Insures More People Than McCain's, Study Says
4 Oct 2008 at 11:32pm
Twice as many uninsured people in the United States will have health insurance in 10 years under Sen. Barack Obama's healthcare plan than under Sen. John McCain's plan, according to a report by the Commonwealth Fund, but a critic challenges the group's projections.
WebMD Health News

Severe Hypoglycemia Does Not Affect Teens' Cognitive Function
6 Oct 2008 at 11:52am
Frequent severe episodes of hypoglycemia associated with intensive diabetes treatment do not adversely affect cognitive function in adolescents with type 1 diabetes, according to findings from the Diabetes Control and Complications Trial (DCCT).
Reuters Health Information

Stroke More Common and More Deadly Among American Indians
6 Oct 2008 at 11:56am
American Indians have a higher incidence of stroke compared with white or black Americans, and they are more apt to die from a first stroke, according to a study published online September 22 in Circulation: Journal of the American Heart Association.
Reuters Health Information

Melanogenesis Inhibition Sensitizes Melanoma Cells to Radiotherapy
6 Oct 2008 at 11:24am
Inhibition of melanogenesis sensitizes melanoma cells in culture to gamma radiation, according to a report in the September 15th International Journal of Cancer.
Reuters Health Information

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